Peroxin 14 Inhibitors
Peroxin 14 inhibitors belong to a specialized chemical class that plays a pivotal role in cellular functions, particularly in the context of peroxisome biogenesis and maintenance. Peroxisomes are membrane-bound organelles responsible for various metabolic processes, including lipid metabolism and detoxification reactions. The biogenesis of peroxisomes involves a series of intricate steps, and peroxin 14 (PEX14) stands out as a crucial component in this intricate machinery. PEX14 serves as a docking site for other peroxins and facilitates the import of proteins into peroxisomes, contributing to the overall structure and functionality of these organelles.
Inhibitors of PEX14 disrupt the normal functioning of peroxisomes by interfering with the protein import process. These compounds typically act by binding to PEX14, inhibiting its ability to interact with other peroxins or cargo proteins destined for peroxisomes. As a consequence, the impaired import machinery compromises the assembly and maintenance of peroxisomes, leading to aberrant cellular metabolism. Understanding the mechanisms underlying peroxisome biogenesis and the role of PEX14 can provide valuable insights into cellular homeostasis and may have implications for various fields, including cell biology and biochemistry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
It inhibits protein synthesis in eukaryotes, which indirectly affects PEX14 function. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
It inhibits RNA synthesis, which indirectly affects protein expression including PEX14. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
It stabilizes microtubules and can potentially influence peroxisome localization, indirectly affecting PEX14. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
It depolymerizes microtubules and can potentially influence peroxisome localization, indirectly affecting PEX14. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
It disrupts the Golgi apparatus and protein trafficking, indirectly affecting PEX14. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
It inhibits N-linked glycosylation, which can potentially affect PEX14 and other peroxisome proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
It inhibits mTOR pathway, which indirectly can affect protein synthesis and turnover including PEX14. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
It increases lysosomal pH, which can affect protein degradation, indirectly affecting PEX14 levels. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
It inhibits the proteasome, which can result in altered protein turnover, indirectly affecting PEX14 levels. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
It inhibits protein transport between ER and Golgi, indirectly affecting PEX14. | ||||||