Peripherin Antibody (8G2): sc-58834
- Peripherin Antibody (8G2) is a mouse monoclonal IgG1 provided at 250 µl supernatant
- raised against recombinant Peripherin of rat origin
- recommended for detection of Peripherin of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Peripherin Antibody (8G2). This work is in progress.
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Peripherin Antibody (8G2) is a mouse monoclonal IgG1 antibody that detects Peripherin in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Peripherin antibody (8G2) is available in a non-conjugated form, allowing for versatile applications in research. Peripherin is a type III intermediate filament protein that plays a crucial role in the structural integrity of peripheral and certain central nervous system neurons. Expression of Peripherin is notably influenced by cytokines such as leukemia inhibitory factor (LIF) and interleukin-6 (IL-6), which activate Peripherin by promoting the binding of Stat transcription factors to specific promoter elements within the Peripherin gene. While Peripherin is not essential for the initial formation of neurites, Peripherin plays a vital role in establishing a robust cellular intermediate filament network, which is important for maintaining neuronal shape and resilience under stress. Peripherin undergoes post-translational modifications, particularly tyrosine phosphorylation, which can affect function and interactions with other proteins, highlighting a dynamic role in neuronal health and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Peripherin Antibody (8G2) References:
- Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. | Nguyen, ON., et al. 2016. Hum Mol Genet. 25: 2367-2377. PMID: 27033727
- Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis. | Molday, RS. and Goldberg, AFX. 2017. J Cell Biol. 216: 1227-1229. PMID: 28400442
- Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin. | Hol, EM. and Capetanaki, Y. 2017. Cold Spring Harb Perspect Biol. 9: PMID: 29196434
- The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases. | Tebbe, L., et al. 2020. Cells. 9: PMID: 32213850
- Role of the Intermediate Filament Protein Peripherin in Health and Disease. | Romano, R., et al. 2022. Int J Mol Sci. 23: PMID: 36499746
- Peripherin is a biomarker of axonal damage in peripheral nervous system disease. | Keddie, S., et al. 2023. Brain. 146: 4562-4573. PMID: 37435933
- The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis. | Lewis, TR., et al. 2023. Adv Exp Med Biol. 1415: 277-281. PMID: 37440045
- Retinal Dystrophies Associated With Peripherin-2: Genetic Spectrum and Novel Clinical Observations in 241 Patients. | Heath Jeffery, RC., et al. 2024. Invest Ophthalmol Vis Sci. 65: 22. PMID: 38743414
- Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders. | Rutan Woods, CT., et al. 2024. Nat Commun. 15: 4756. PMID: 38834544
- The role of the peripherin/RDS gene in retinal dystrophies. | Kohl, S., et al. 1998. Acta Anat (Basel). 162: 75-84. PMID: 9831753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Peripherin Antibody (8G2) | sc-58834 | 250 µl supernatant | $322.00 |