PEN-2 Antibody (1C12-G5): sc-293392
- PEN-2 Antibody (1C12-G5) is a mouse monoclonal IgG1 κ PEN-2 antibody provided at 100 µg/ml
- raised against amino acids 1-101 of PEN-2 of human origin
- recommended for detection of PEN-2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PEN-2 Antibody (1C12-G5). This work is in progress.
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PEN-2 Antibody (1C12-G5) is a mouse monoclonal IgG1 kappa light chain antibody that detects PEN-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PEN-2 antibody (1C12-G5) is available as the non-conjugated format. PEN-2 plays a crucial role in the assembly and function of the gamma-secretase complex, which is essential for the proteolytic processing of type I membrane proteins, including the amyloid-beta precursor protein. This processing is particularly significant as PEN-2 is linked to the pathogenesis of Alzheimer′s disease, where the accumulation of amyloid-beta peptides is a hallmark. The gamma-secretase complex, composed of presenilin, nicastrin, aph-1, and PEN-2, assembles in the Golgi/trans-Golgi network compartments, leading to the autocleavage of presenilin into two subunits that form the active site of gamma-secretase. Understanding the structure and function of PEN-2 and its interactions within this complex is vital for elucidating the mechanisms underlying Alzheimer′s disease and developing potential therapeutic strategies.
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PEN-2 Antibody (1C12-G5) References:
- Gamma-secretase--intramembrane protease with a complex. | Wolfe, MS. 2003. Sci Aging Knowledge Environ. 2003: PE7. PMID: 12844518
- Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. | Baulac, S., et al. 2003. Neurobiol Dis. 14: 194-204. PMID: 14572442
- Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex. | Fortna, RR., et al. 2004. J Biol Chem. 279: 3685-93. PMID: 14593096
- Identity and function of gamma-secretase. | Kimberly, WT. and Wolfe, MS. 2003. J Neurosci Res. 74: 353-60. PMID: 14598311
- Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin. | Bergman, A., et al. 2004. J Biol Chem. 279: 16744-53. PMID: 14724271
- Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. | Prokop, S., et al. 2004. J Biol Chem. 279: 23255-61. PMID: 15039426
- Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. | Hasegawa, H., et al. 2004. J Biol Chem. 279: 46455-63. PMID: 15322109
- PEN-2 enhances gamma-cleavage after presenilin heterodimer formation. | Shiraishi, H., et al. 2004. J Neurochem. 90: 1402-13. PMID: 15341524
- A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. | Kim, SH. and Sisodia, SS. 2005. J Biol Chem. 280: 1992-2001. PMID: 15537629
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PEN-2 Antibody (1C12-G5) | sc-293392 | 100 µg/ml | $322.00 |