CD31/PECAM-1 Antibody (TLD-4E8): sc-53526
- CD31/PECAM-1 Antibody (TLD-4E8) is a mouse monoclonal IgG1, cited in 6 publications, provided at 200 µg/ml
- raised against activated microglial cells of Lewis rat origin
- recommended for detection of PECAM-1 of mouse and rat origin by IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD31/PECAM-1 (H-3): sc-376764 for CD31/PECAM-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD31/PECAM-1 Antibody (TLD-4E8). This work is in progress.
QUICK LINKS
PECAM-1 Antibody (TLD-4E8) is a mouse monoclonal IgG1 antibody that detects PECAM-1 in mouse and rat samples through immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM) applications. PECAM-1, also known as CD31, is a crucial glycoprotein predominantly expressed on the surfaces of endothelial cells, platelets, and certain leukocyte populations, playing a vital role in mediating cell-cell adhesion and transendothelial migration. PECAM-1 is essential for maintaining vascular integrity and regulating inflammatory responses, as PECAM-1 facilitates the movement of immune cells from the bloodstream into tissues during immune responses. The interaction of PECAM-1 with other adhesion molecules, such as integrins, is critical for the proper functioning of the immune system and the maintenance of vascular homeostasis. Additionally, PECAM-1 is involved in angiogenesis and wound healing, making PECAM-1 a significant target for research in cardiovascular diseases and cancer. With proven detection capabilities in multiple applications, anti-PECAM-1 antibody (TLD-4E8) serves as an invaluable tool for researchers studying these complex biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD31/PECAM-1 Antibody (TLD-4E8) References:
- Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration. | Bird, IN., et al. 1999. J Cell Sci. 112 (Pt 12): 1989-97. PMID: 10343075
- Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane. | Thompson, RD., et al. 2001. Blood. 97: 1854-60. PMID: 11238129
- Regulation of PECAM-1 in endothelial cells during cell growth and migration. | RayChaudhury, A., et al. 2001. Exp Biol Med (Maywood). 226: 686-91. PMID: 11444105
- Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia. | Nolte, D., et al. 2004. Eur Surg Res. 36: 331-7. PMID: 15591740
- Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature. | Ding, BS., et al. 2008. Blood. 111: 1999-2006. PMID: 18045968
- Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice. | Goel, R., et al. 2008. Arterioscler Thromb Vasc Biol. 28: 1996-2002. PMID: 18669884
- Heparan sulfates mediate the interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and the Gαq/11 subunits of heterotrimeric G proteins. | dela Paz, NG., et al. 2014. J Biol Chem. 289: 7413-24. PMID: 24497640
- Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. | Kalra, VK., et al. 1996. Am J Physiol. 271: H2025-34. PMID: 8945922
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD31/PECAM-1 Antibody (TLD-4E8) | sc-53526 | 200 µg/ml | $316.00 | |||
CD31/PECAM-1 Antibody (TLD-4E8) FITC | sc-53526 FITC | 200 µg/ml | $330.00 | |||
CD31/PECAM-1 Antibody (TLD-4E8) PE | sc-53526 PE | 200 µg/ml | $343.00 |