CD31/PECAM-1 Antibody (2F7B2): sc-81158

PECAM-1 Antibody (2F7B2) is a mouse monoclonal IgG1 antibody that detects PECAM-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PECAM-1, also known as CD31, is a crucial glycoprotein expressed on the surfaces of endothelial cells, platelets, and certain immune cells, playing a vital role in mediating cell-cell adhesion and transendothelial migration of leukocytes. This function is particularly important in inflammation and immune response, as PECAM-1 facilitates the movement of immune cells from the bloodstream into tissues, contributing to the body′s defense mechanisms. Additionally, PECAM-1 is involved in maintaining vascular barrier integrity, which is essential for preventing excessive leakage of fluids and proteins into surrounding tissues. PECAM-1 expression is also associated with various pathological conditions, including cancer, where PECAM-1 can influence tumor progression and metastasis. With significant roles in both normal physiology and disease processes, anti-PECAM-1 antibody (2F7B2) serves as a valuable tool for researchers investigating vascular biology, immunology, and cancer research.

The preferred CD31/PECAM-1 antibody is CD31/PECAM-1 Antibody (MEC 13.3): sc-18916.