PDRG Antibody (C-9): sc-398815

PDRG Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects PDRG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDRG (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PDRG protein, also known as p53 and DNA damage regulated or C20orf126, is a 133 amino acid protein that is primarily localized in the cytoplasm and belongs to the prefoldin subunit beta family. PDRG protein plays a crucial role in chaperone-mediated protein folding, which is essential for maintaining cellular homeostasis and preventing the accumulation of misfolded proteins that can lead to cellular stress and disease. PDRG protein is predominantly expressed in normal testicular tissue and is functionally induced by ultraviolet light, highlighting its importance in cellular responses to DNA damage. The gene encoding PDRG is located on human chromosome 20, a region that contains over 600 genes, some of which are implicated in various neurodegenerative diseases and syndromes, including Creutzfeldt-Jakob disease and amyotrophic lateral sclerosis. Furthermore, chromosome 20 harbors genes that are significant for seminal production, suggesting potential avenues for male contraception research.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PDRG Antibody (C-9) References:

1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation.  |  Luo, X., et al. 2003. Oncogene. 22: 7247-57. PMID: 14562055
2. p53 and p21WAF1/CIP1 overexpression at the invasive front of lower lip squamous cell carcinoma.  |  Horta, MC., et al. 2007. J Oral Pathol Med. 36: 88-92. PMID: 17238970
3. Significantly greater expression of ER, PR, and ECAD in advanced-stage low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis.  |  Wong, KK., et al. 2007. Int J Gynecol Pathol. 26: 404-9. PMID: 17885490
4. Alteration of cell-cycle regulation in epithelial ovarian cancer.  |  Nam, EJ. and Kim, YT. 2008. Int J Gynecol Cancer. 18: 1169-82. PMID: 18298566
5. The expression of p53 in invasive ductal carcinoma of the breast: a study in the North-East States of Malaysia.  |  Al-Joudi, FS., et al. 2008. Med J Malaysia. 63: 96-9. PMID: 18942291
6. DEK proto-oncogene expression interferes with the normal epithelial differentiation program.  |  Wise-Draper, TM., et al. 2009. Am J Pathol. 174: 71-81. PMID: 19036808

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDRG Antibody (C-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PDRG Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDRG Antibody (C-9) Specifications

Alternate Product Name: PDRG

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 3-133

Epitope Target: PDRG

Epitope Species: human

Product Reactivity/Detection: PDRG

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PDRG Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin