PDLIM5 Antibody (G-2): sc-515621
- PDLIM5 Antibody (G-2) is a mouse monoclonal IgG1 κ PDLIM5 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 297-596 mapping at the C-terminus of PDLIM5 of human origin
- PDLIM5 Antibody (G-2) is recommended for detection of PDLIM5 of human origin by WB, IP, IF and ELISA
- Anti-PDLIM5 Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDLIM5 Antibody (G-2). This work is in progress.
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PDLIM5 Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDLIM5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PDLIM5 antibody (G-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PDLIM5, also known as PDZ and LIM domain 5, L9, ENH (Enigma homolog), or ENH1, is a crucial member of the Enigma family of proteins, characterized by an N-terminal PDZ domain and one to three C-terminal LIM domains. These structural features enable PDLIM5 to interact with various isoforms of protein kinase C, playing a significant role in cellular signaling pathways. PDLIM5 is predominantly expressed in the brain, where PDLIM5 colocalizes with synaptic vesicles and is involved in regulating neuronal calcium signaling through interactions with PKC ε and the N-type calcium channel α1B subunit. This regulation is vital for neurotransmitter release and synaptic plasticity, processes that are essential for learning and memory. Alterations in PDLIM5 expression have been linked to neuropsychiatric disorders such as schizophrenia, major depression, and bipolar disorder, indicating PDLIM5′s potential role in the genetic susceptibility to these conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PDLIM5 Antibody (G-2) References:
- Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP). | Wu, M., et al. 2004. DNA Seq. 15: 144-7. PMID: 15346770
- Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. | Kato, T., et al. 2005. Mol Psychiatry. 10: 1045-55. PMID: 16044170
- A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia. | Horiuchi, Y., et al. 2006. Biol Psychiatry. 59: 434-9. PMID: 16213469
- Gene expression and association analysis of LIM (PDLIM5) in major depression. | Iga, J., et al. 2006. Neurosci Lett. 400: 203-7. PMID: 16595163
- Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia. | Numata, S., et al. 2007. Neurosci Lett. 415: 28-33. PMID: 17287082
- Positive association between PDLIM5 and schizophrenia in the Chinese Han population. | Li, C., et al. 2008. Int J Neuropsychopharmacol. 11: 27-34. PMID: 18021463
- A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. | Liu, Z., et al. 2008. J Psychiatry Neurosci. 33: 43-6. PMID: 18197271
- Protein-protein interaction of zinc finger LIM domains with protein kinase C. | Kuroda, S., et al. 1996. J Biol Chem. 271: 31029-32. PMID: 8940095
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDLIM5 Antibody (G-2) | sc-515621 | 200 µg/ml | $322.00 | |||
PDLIM5 Antibody (G-2) AC | sc-515621 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PDLIM5 Antibody (G-2) HRP | sc-515621 HRP | 200 µg/ml | $322.00 | |||
PDLIM5 Antibody (G-2) FITC | sc-515621 FITC | 200 µg/ml | $336.00 | |||
PDLIM5 Antibody (G-2) PE | sc-515621 PE | 200 µg/ml | $349.00 | |||
PDLIM5 Antibody (G-2) Alexa Fluor® 488 | sc-515621 AF488 | 200 µg/ml | $364.00 | |||
PDLIM5 Antibody (G-2) Alexa Fluor® 546 | sc-515621 AF546 | 200 µg/ml | $364.00 | |||
PDLIM5 Antibody (G-2) Alexa Fluor® 594 | sc-515621 AF594 | 200 µg/ml | $364.00 | |||
PDLIM5 Antibody (G-2) Alexa Fluor® 647 | sc-515621 AF647 | 200 µg/ml | $364.00 | |||
PDLIM5 Antibody (G-2) Alexa Fluor® 680 | sc-515621 AF680 | 200 µg/ml | $364.00 | |||
PDLIM5 Antibody (G-2) Alexa Fluor® 790 | sc-515621 AF790 | 200 µg/ml | $364.00 |