PDIR Antibody (H-8): sc-376164

PDIR Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects PDIR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDIR, or Protein Disulfide Isomerase-Related Protein, is a crucial 519 amino acid protein that plays a significant role in the endoplasmic reticulum by catalyzing the rearrangement of disulfide bonds in newly synthesized proteins, thereby ensuring proper protein folding and functionality. PDIR (H-8) antibody recognizes a protein essential for assisting in the oxidative refolding of proteins, particularly α1-antitrypsin, which is vital for maintaining protease inhibition in the bloodstream and preventing tissue damage. PDIR is localized to the lumen of the endoplasmic reticulum, where PDIR not only facilitates the formation of disulfide bonds but also acts as a molecular chaperone, preventing misfolded proteins from aggregating. PDIR features an ER retention signal at its C-terminus and three thioredoxin motifs that are essential for substrate-specific isomerase, chaperone, and redox activities. anti-PDIR antibody (H-8) is an invaluable tool for researchers studying protein folding disorders and the molecular mechanisms underlying various diseases.

The preferred PDIR antibody is PDIR Antibody (B-9): sc-390862.