PDIR Antibody (C-2): sc-365500
- PDIR Antibody (C-2) is a mouse monoclonal IgM, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 259-293 within an internal region of PDIR of human origin
- recommended for detection of PDIR of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDIR Antibody (C-2). This work is in progress.
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PDIR Antibody (C-2) is a mouse monoclonal IgM antibody that detects PDIR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDIR, or Protein Disulfide Isomerase-Related Protein, is a crucial 519 amino acid protein that plays a significant role in the endoplasmic reticulum by catalyzing the rearrangement of disulfide bonds in newly synthesized proteins, which is essential for proper protein folding and function. PDIR′s localization within the lumen of the endoplasmic reticulum is vital, as PDIR provides an environment conducive to oxidative refolding, particularly for proteins like α1-antitrypsin, which require the formation of disulfide bonds for their stability and activity. PDIR contains a C-terminal ER retention signal and three thioredoxin motifs that are integral to PDIR′s substrate-specific isomerase, chaperone, and redox activities, highlighting PDIR′s multifaceted role in maintaining cellular protein homeostasis. Anti-PDIR antibody (C-2) is an invaluable tool for researchers studying protein folding disorders and the molecular mechanisms underlying various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDIR Antibody (C-2) | sc-365500 | 200 µg/ml | $322.00 | |||
PDIR (C-2) Neutralizing Peptide | sc-365500 P | 100 µg/0.5 ml | $69.00 |