PDI Antibody (F-11): sc-166474

PDI Antibody (F-11) is a mouse monoclonal IgG3 antibody that detects protein disulfide isomerase (PDI) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-PDI antibody (F-11) recognizes PDI, a crucial protein that plays a significant role in the folding and maturation of newly synthesized proteins within the endoplasmic reticulum (ER). PDI (F-11) antibody targets a protein essential for maintaining cellular homeostasis, as PDI catalyzes thiol-disulfide exchange reactions, which are vital for proper formation of disulfide bonds in proteins. PDI functions as a molecular chaperone to aid in correct protein folding and prevent aggregation of misfolded proteins, contributing to cellular stress responses. PDI engages in critical interactions with other proteins, such as immunoglobulin heavy chain binding protein (BiP), enhancing protein processing and quality control within the ER. PDI localization in the ER enables immediate assistance in protein folding during synthesis, ensuring proteins reach functional conformations efficiently. With diverse functions and interactions, PDI serves as a key player in cellular physiology, making PDI (F-11) monoclonal antibody an invaluable tool for researchers studying protein folding and related cellular processes.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

PDI Antibody (F-11) References:

1. Endo-PDI is required for TNFα-induced angiogenesis.  |  Camargo, LL., et al. 2013. Free Radic Biol Med. 65: 1398-1407. PMID: 24103565
2. Protein Disulphide Isomerases: emerging roles of PDI and ERp57 in the nervous system and as therapeutic targets for ALS.  |  Perri, E., et al. 2017. Expert Opin Ther Targets. 21: 37-49. PMID: 27786579
3. PDI regulates seizure activity via NMDA receptor redox in rats.  |  Kim, JY., et al. 2017. Sci Rep. 7: 42491. PMID: 28198441
4. PDI Family Members as Guides for Client Folding and Assembly.  |  Kanemura, S., et al. 2020. Int J Mol Sci. 21: PMID: 33302492
5. PDI-Regulated Disulfide Bond Formation in Protein Folding and Biomolecular Assembly.  |  Fu, J., et al. 2020. Molecules. 26: PMID: 33396541
6. Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement Under Flow.  |  Dupuy, A., et al. 2023. Circ Res. 132: e151-e168. PMID: 37021588
7. Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI-GRP94-GPIIb/IIIa Pathway in Mice.  |  Lan, H., et al. 2023. J Clin Med. 12: PMID: 37445300
8. PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus.  |  Lee, DS., et al. 2023. Sci Rep. 13: 13927. PMID: 37626185
9. PDI-Based Organic Small Molecule Regulated by Inter/Intramolecular Interactions for Efficient Solar Vapor Generation.  |  Shao, C., et al. 2023. Small. 19: e2305856. PMID: 37635112
10. Novel PDI-NH/PDI-COOH Supramolecular Junction for Enhanced Visible-Light Photocatalytic Phenol Degradation.  |  Xu, Y., et al. 2024. Molecules. 29: PMID: 39275044

The preferred PDI antibody is PDI Antibody (C-2): sc-74551.