PDGFRL Antibody (F-2): sc-393355
- PDGFRL Antibody (F-2) is a mouse monoclonal IgG1 κ PDGFRL antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 23-54 near the N-terminus of PDGFRL of human origin
- PDGFRL Antibody (F-2) is recommended for detection of PDGFRL of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PDGFRL Antibody (F-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PDGFRL Antibody (F-2) for WB applications. This reagent is now offered in a bundle with PDGFRL Antibody (F-2) (see ordering information below).
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PDGFRL Antibody (F-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDGFRL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PDGFRL antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PDGFRL, also known as platelet-derived growth factor receptor-like protein, is a 375 amino acid secreted protein that shares significant sequence similarity with the extracellular domain of PDGFR-β. PDGFRL is primarily located in the extracellular space, where PDGFRL plays a crucial role in cell signaling pathways that regulate cell growth and differentiation. PDGFRL localization is particularly important as PDGFRL allows for the modulation of ligand activity, which can influence tumorigenesis. PDGFRL gene is situated on chromosome 18, a region frequently mutated in various cancers, including colorectal cancers, hepatocellular carcinomas, and non-small cell lung cancers. Mutations in PDGFRL, such as a somatic mutation at codon 23 in colorectal cancers and a two base pair deletion at codon 175 in hepatocellular carcinomas, highlight PDGFRL′s potential role as a tumor suppressor. PDGFRL is preferentially expressed in normal liver, lung, and colon tissues, suggesting PDGFRL′s involvement in maintaining normal cellular functions and potential as a therapeutic target in cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PDGFRL Antibody (F-2) References:
- Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis. | Bo, H., et al. 2004. J Nippon Med Sch. 71: 172-80. PMID: 15226608
- Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. | Pils, D., et al. 2005. Cancer. 104: 2417-29. PMID: 16270321
- Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression. | Seitz, S., et al. 2006. Genes Chromosomes Cancer. 45: 612-27. PMID: 16552773
- Laser capture-microarray analysis of Lim1 mutant kidney development. | Potter, SS., et al. 2007. Genesis. 45: 432-9. PMID: 17610272
- An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer. | Xu, M., et al. 2008. BMC Genomics. 9 Suppl 1: S12. PMID: 18366601
- A 3-Mb physical map of the chromosome region 8p21.3-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer. | Fujiwara, Y., et al. 1994. Genes Chromosomes Cancer. 10: 7-14. PMID: 7519877
- Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. | Fujiwara, Y., et al. 1995. Oncogene. 10: 891-5. PMID: 7898930
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDGFRL Antibody (F-2) | sc-393355 | 200 µg/ml | $322.00 | |||
PDGFRL Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-526241 | 200 µg Ab; 10 µg BP | $361.00 | |||
PDGFRL Antibody (F-2) AC | sc-393355 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PDGFRL Antibody (F-2) HRP | sc-393355 HRP | 200 µg/ml | $322.00 | |||
PDGFRL Antibody (F-2) FITC | sc-393355 FITC | 200 µg/ml | $336.00 | |||
PDGFRL Antibody (F-2) PE | sc-393355 PE | 200 µg/ml | $349.00 | |||
PDGFRL Antibody (F-2) Alexa Fluor® 488 | sc-393355 AF488 | 200 µg/ml | $364.00 | |||
PDGFRL Antibody (F-2) Alexa Fluor® 546 | sc-393355 AF546 | 200 µg/ml | $364.00 | |||
PDGFRL Antibody (F-2) Alexa Fluor® 594 | sc-393355 AF594 | 200 µg/ml | $364.00 | |||
PDGFRL Antibody (F-2) Alexa Fluor® 647 | sc-393355 AF647 | 200 µg/ml | $364.00 | |||
PDGFRL Antibody (F-2) Alexa Fluor® 680 | sc-393355 AF680 | 200 µg/ml | $364.00 | |||
PDGFRL Antibody (F-2) Alexa Fluor® 790 | sc-393355 AF790 | 200 µg/ml | $364.00 | |||
PDGFRL (F-2) Neutralizing Peptide | sc-393355 P | 100 µg/0.5 ml | $69.00 |