PDGF Receptor alpha/PDGFRA Antibody (C-9): sc-398206

PDGFR-α Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDGFR-alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-PDGFR-α antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Platelet-derived growth factor receptor alpha (PDGFR-α) plays a crucial role in cell signaling pathways that regulate cell proliferation, survival, and migration, making PDGFR-α essential for normal development and tissue repair. PDGFR-α is primarily located on the cell surface, where PDGFR-α interacts with platelet-derived growth factor (PDGF) isoforms to initiate signaling cascades that influence cellular behavior. PDGFR-α′s ability to form homo- and heterodimers upon ligand binding is vital for function, as this formation determines the specificity and strength of the signaling response. PDGFR-α can bind to both PDGF-A and PDGF-B chains, leading to distinct receptor dimers that activate different downstream pathways. Dysregulation of PDGFR-α signaling has been implicated in various diseases, including cancer, where aberrant activation can promote tumor growth and metastasis. Understanding PDGFR-α′s role in these processes highlights PDGFR-α′s potential as a therapeutic target, making PDGFR-α monoclonal antibody (C-9) an invaluable tool for researchers studying function and implications in health and disease.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDGF Receptor alpha/PDGFRA Antibody (C-9) has 47 citations in a variety of scientific publications.

Primary antibodies like Anti-PDGF Receptor alpha/PDGFRA Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDGF Receptor alpha/PDGFRA Antibody (C-9) Specifications

Alternate Product Name: PDGFR alpha

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 951-1089

Epitope Target: PDGFR-α

Epitope Species: human

Product Reactivity/Detection: PDGFR-α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 47 citations in various scientific publications

Available Conjugates/Forms for PDGF Receptor alpha/PDGFRA Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PDGF Receptor alpha/PDGFRA antibody is PDGF Receptor alpha/PDGFRA Antibody (16A1): sc-21789.