PDGF Receptor alpha/PDGFRA Antibody (16A1): sc-21789

PDGFR-α Antibody (16A1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDGFR-α in mouse, rat, and human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Anti-PDGFR-α antibody (16A1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The platelet-derived growth factor receptor alpha (PDGFR-α) plays a crucial role in cellular processes such as proliferation, survival, and migration, making PDGFR-α essential for normal development and tissue repair. PDGFR-α is primarily located on the cell surface, where PDGFR-α interacts with PDGF-AA and PDGF-AB ligands to initiate signaling cascades that influence cell behavior. PDGFR-α′s ability to form homodimers and heterodimers upon ligand binding is vital for function, as this formation determines the specificity and strength of the signaling response. Dysregulation of PDGFR-α signaling has been implicated in various pathologies, including cancer and fibrotic diseases, highlighting PDGFR-α′s importance in both health and disease. PDGFR-α monoclonal antibody (16A1) serves as an invaluable tool for researchers studying these critical biological processes and their implications in disease.

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PDGF Receptor alpha/PDGFRA Antibody (16A1) References:

1. Regulation of PDGFR-alpha in rat pulmonary myofibroblasts by staurosporine.  |  Lindroos, PM., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 280: L354-62. PMID: 11159015
2. Anti-PDGFR-alpha antibodies measured by non-bioactivity assays are not specific for systemic sclerosis.  |  Balada, E., et al. 2008. Ann Rheum Dis. 67: 1027-9. PMID: 18272670
3. PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage.  |  Ma, Q., et al. 2011. Ann Neurol. 70: 920-31. PMID: 22190365
4. Expression and significance of Ku80 and PDGFR-α in nasal NK/T-cell lymphoma.  |  Li, J., et al. 2016. Pathol Res Pract. 212: 204-9. PMID: 26778387
5. Two classes of PDGF receptor recognize different isoforms of PDGF.  |  Hart, CE., et al. 1988. Science. 240: 1529-31. PMID: 2836952
6. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.  |  Heldin, CH., et al. 1988. EMBO J. 7: 1387-93. PMID: 2842148
7. The biology of platelet-derived growth factor.  |  Ross, R., et al. 1986. Cell. 46: 155-69. PMID: 3013421
8. Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis.  |  Murayama, E., et al. 2023. Nat Commun. 14: 1171. PMID: 36859431
9. PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.  |  Zheng, H., et al. 2024. Cancer Cell. 42: 682-700.e12. PMID: 38428409
10. Immunohistochemical analysis of PDGFR-α for wound age determination.  |  Zhang, W., et al. 2024. Int J Legal Med. 138: 1351-1356. PMID: 38520552
11. A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.  |  Rupp, E., et al. 1994. Eur J Biochem. 225: 29-41. PMID: 7523122
12. Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.  |  Bazenet, CE., et al. 1996. Mol Cell Biol. 16: 6926-36. PMID: 8943348

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDGF Receptor alpha/PDGFRA Antibody (16A1) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-PDGF Receptor alpha/PDGFRA Antibody (16A1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDGF Receptor alpha/PDGFRA Antibody (16A1) Specifications

Alternate Product Name: PDGFR alpha

Product Clone Name: 16A1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PDGFR-α

Epitope Species: human

Product Reactivity/Detection: PDGFR-α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for PDGF Receptor alpha/PDGFRA Antibody (16A1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PDGF Receptor alpha/PDGFRA antibody is PDGF Receptor alpha/PDGFRA Antibody (C-9): sc-398206.