PDE5A Antibody (54): sc-136027
- PDE5A Antibody (54) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 2-108 of PDE5A of rat origin
- recommended for detection of PDE5A of mouse and rat origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDE5A Antibody (54). This work is in progress.
PDE5A Antibody (54) is a mouse monoclonal IgG1 antibody that recognizes PDE5A in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). PDE5A, also known as cGMP-binding cGMP-specific phosphodiesterase, plays a crucial role in regulating intracellular levels of cyclic nucleotides, specifically by catalyzing the hydrolysis of cyclic guanosine monophosphate (cGMP) to 5′GMP. This regulation is vital for various physiological processes, including smooth muscle relaxation and signal transduction pathways that influence cardiovascular function. PDE5A is predominantly expressed in tissues such as the heart, placenta, aortic smooth muscle cells, skeletal muscle, and pancreas, highlighting PDE5A′s importance in both cardiac and vascular health. By modulating cGMP levels, PDE5A is integral to the relaxation of smooth muscle and the regulation of blood flow, making PDE5A a significant target for therapeutic interventions in conditions like pulmonary hypertension and erectile dysfunction. Anti-PDE5A antibody (54) provides a reliable tool for researchers aiming to explore the functional dynamics of PDE5A in various biological contexts.
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PDE5A Antibody (54) References:
- Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity. | Gebska, MA., et al. 2011. Cardiovasc Res. 90: 353-63. PMID: 21421555
- Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A. | Carøe Nordgaard, J., et al. 2014. PLoS One. 9: e107627. PMID: 25247292
- PDE5A Polymorphisms Influence on Sildenafil Treatment Success. | Marchal-Escalona, C., et al. 2016. J Sex Med. 13: 1104-10. PMID: 27235284
- PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes. | Liu, W., et al. 2019. Int J Endocrinol. 2019: 3054820. PMID: 30774657
- Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models. | Liao, M., et al. 2022. Pharmacol Res. 176: 106077. PMID: 35026404
- Impaired Platelet Function and Thrombus Formation in PDE5A-Deficient Mice. | Gui, X., et al. 2023. Thromb Haemost. 123: 207-218. PMID: 36252813
- A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors. | Ma, Y., et al. 2023. Front Chem. 11: 1097027. PMID: 36860644
- OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes. | Wang, Q., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167018. PMID: 38185350
- miR-30d Attenuates Pulmonary Arterial Hypertension via Targeting MTDH and PDE5A and Modulates the Beneficial Effect of Sildenafil. | Liang, X., et al. 2024. Adv Sci (Weinh). 11: e2407712. PMID: 39206778
- Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene. | Yanaka, N., et al. 1998. Eur J Biochem. 255: 391-9. PMID: 9716380
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDE5A Antibody (54) | sc-136027 | 50 µg/0.5 ml | $322.00 |