PDE3A Antibody (2D7): sc-293446

PDE3A Antibody (2D7) is a mouse monoclonal IgG2b kappa light chain antibody that detects PDE3A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PDE3A antibody (2D7) is available as a non-conjugated format. PDE3A plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a vital second messenger involved in various cellular processes, including cardiac function and platelet aggregation. By hydrolyzing cAMP to 5′AMP, PDE3A helps modulate signaling pathways that influence myocardial contractility and smooth muscle relaxation, making PDE3A essential for maintaining cardiovascular health. PDE3A expression is primarily localized in the myocardium and platelets, where PDE3A contributes to the fine-tuning of heart muscle contractions and the aggregation of platelets during hemostasis. Understanding PDE3A function and regulatory mechanisms is important for developing therapeutic strategies targeting cardiovascular diseases and disorders related to platelet function.

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PDE3A Antibody (2D7) References:

1. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.  |  Hetman, JM., et al. 2000. Proc Natl Acad Sci U S A. 97: 472-6. PMID: 10618442
2. Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene.  |  Kasuya, J., et al. 2000. Biochem Biophys Res Commun. 268: 827-34. PMID: 10679291
3. Hypothalamic PDE3B deficiency alters body weight and glucose homeostasis in mouse.  |  Sahu, M., et al. 2018. J Endocrinol. 239: 93-105. PMID: 30307157
4. PDE3B regulates KRT6B and increases the sensitivity of bladder cancer cells to copper ionophores.  |  Feng, Y., et al. 2024. Naunyn Schmiedebergs Arch Pharmacol. 397: 4911-4925. PMID: 38165426
5. Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.  |  Rowley, AM., et al. 2024. J Med Chem. 67: 2049-2065. PMID: 38284310
6. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants.  |  Bloom, TJ. and Beavo, JA. 1996. Proc Natl Acad Sci U S A. 93: 14188-92. PMID: 8943082
7. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.  |  Han, P., et al. 1997. J Biol Chem. 272: 16152-7. PMID: 9195912
8. Cyclic AMP phosphodiesterases in human lymphocytes.  |  Sheth, SB., et al. 1997. Br J Haematol. 99: 784-9. PMID: 9432022
9. Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation.  |  Gantner, F., et al. 1998. Br J Pharmacol. 123: 1031-8. PMID: 9559883
10. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.  |  Fisher, DA., et al. 1998. Biochem Biophys Res Commun. 246: 570-7. PMID: 9618252
11. Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.  |  Cheung, PP., et al. 1998. Arch Biochem Biophys. 360: 99-104. PMID: 9826434
12. Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP.  |  Liu, H. and Maurice, DH. 1998. Br J Pharmacol. 125: 1501-10. PMID: 9884079

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PDE3A Antibody (2D7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PDE3A Antibody (2D7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PDE3A Antibody (2D7) Specifications

Alternate Product Name: PDE3A

Product Clone Name: 2D7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 533-640

Epitope Target: PDE3A

Epitope Species: human

Product Reactivity/Detection: PDE3A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 50 µg IgG_2b kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PDE3A Antibody (2D7): N/A