Pdcd-1 Antibody (RMP1-14): sc-73402
- Pdcd-1 Antibody (RMP1-14) is a rat monoclonal IgG2a, cited in 2 publications, provided at 200 µg/ml
- raised against PD-1 transfected BHK cells of mouse origin
- recommended for detection of Pdcd-1 of mouse and rat origin by WB, IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pdcd-1 Antibody (RMP1-14). This work is in progress.
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Pdcd-1 Antibody (RMP1-14) is a rat monoclonal IgG2a light chain antibody that detects the Programmed Cell Death-1 protein (Pdcd-1) of mouse and rat species by western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Anti-Pdcd-1 antibody (RMP1-14) recognizes a type I transmembrane receptor that plays a crucial role in regulating immune responses, particularly in T cell activation and tolerance. Pdcd-1 (RMP1-14) monoclonal antibody detects this protein primarily on the surface of activated T cells, B cells, and myeloid cells, where Pdcd-1 functions as a negative regulator of immune signaling. Pdcd-1 expression on immune cells is vital for maintaining immune homeostasis and preventing autoimmunity by inhibiting excessive T cell activation and proliferation. When Pdcd-1 interacts with PD-L1 and PD-L2 ligands, phosphatases like SHP-1 and SHIP are recruited, dampening T cell receptor signaling. This mechanism is particularly important in tumor microenvironments, where cancer cells often exploit Pdcd-1 pathway to evade immune detection. Anti-Pdcd-1 antibody (RMP1-14) enables researchers to gain valuable insights into immune response regulation and potential therapeutic targets for enhancing anti-tumor immunity.
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Pdcd-1 Antibody (RMP1-14) References:
- Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility. | Hiromine, Y., et al. 2006. Ann N Y Acad Sci. 1079: 285-8. PMID: 17130567
- Effects of tumor necrosis factor inhibitor on serum level of HLA-B27 and PDCD-1 in patients with ankylosing spondylitis. | Chen, X., et al. 2014. Cell Biochem Biophys. 70: 1453-7. PMID: 25005770
- High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer. | Janikovits, J., et al. 2018. Oncoimmunology. 7: e1390640. PMID: 29308317
- Effects of the programmed cell death 1 (PDCD1) polymorphisms in susceptibility to systemic lupus erythematosus. | Fathi, F., et al. 2020. Int J Immunogenet. 47: 57-64. PMID: 31565862
- PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases. | De Re, V., et al. 2021. Liver Int. 41: 133-149. PMID: 32937024
- Programmed cell death 1 (PDCD1) gene haplotypes and susceptibility of patients to basal cell carcinoma. | Fathi, F., et al. 2021. Mol Biol Rep. 48: 2047-2052. PMID: 33389528
- Relationship of PD-1 (PDCD1) and PD-L1 (CD274) Single Nucleotide Polymorphisms with Polycystic Ovary Syndrome. | Han, R., et al. 2021. Biomed Res Int. 2021: 9596358. PMID: 33521133
- Increased PD-1 Level in Severe Cervical Injury Is Associated With the Rare Programmed Cell Death 1 (PDCD1) rs36084323 A Allele in a Dominant Model. | da Silva, MC., et al. 2021. Front Cell Infect Microbiol. 11: 587932. PMID: 34290992
- PDCD1 (PD-1) is a direct target of miR-15a-5p and miR-16-5p. | Palamarchuk, A., et al. 2022. Signal Transduct Target Ther. 7: 12. PMID: 35042864
- CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells. | Ren, L., et al. 2023. Mol Oncol. 17: 2694-2708. PMID: 37691307
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pdcd-1 Antibody (RMP1-14) | sc-73402 | 200 µg/ml | $322.00 |