PD-ECGF Antibody (PGF-44C): sc-47702
- PD-ECGF Antibody (PGF-44C) is a mouse monoclonal IgG1 κ PD-ECGF antibody, cited in 18 publications, provided at 200 µg/ml
- raised against full length recombinant PD-ECGF of human origin
- PD-ECGF Antibody (PGF-44C) is recommended for detection of PD-ECGF of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PD-ECGF Antibody (PGF-44C) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PD-ECGF Antibody (PGF-44C) for WB and IHC(P) applications. These reagents are now offered in bundles with PD-ECGF Antibody (PGF-44C) (see ordering information below).
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PD-ECGF Antibody (PGF-44C) is a mouse monoclonal IgG1 kappa light chain antibody that detects PD-ECGF protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PD-ECGF antibody (PGF-44C) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Platelet-derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase or gliostatin, plays a crucial role in angiogenesis by stimulating endothelial cell proliferation and inducing chemotaxis, which is vital for tissue repair and regeneration. PD-ECGF is primarily located in platelets, placenta, foreskin fibroblasts, and various squamous cell carcinomas, where PD-ECGF is slowly secreted, highlighting its importance in both normal physiological processes and pathological conditions. Notably, PD-ECGF exists as a functional dimer composed of two polypeptide chains, and PD-ECGF overexpression has been linked to tumor progression and the pathophysiology of psoriasis, suggesting its potential as a therapeutic target. Additionally, PD-ECGF exhibits thymidine phosphorylase activity, catalyzing the reversible phosphorolysis of thymidine to thymine in an ATP-dependent manner, which underscores its multifaceted role in nucleotide metabolism and cellular signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PD-ECGF Antibody (PGF-44C) References:
- Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor. | Asai, K., et al. 1992. J Biol Chem. 267: 20311-6. PMID: 1400349
- Platelet-derived endothelial cell growth factor. Pharmacokinetics, organ distribution and degradation after intravenous administration in rats. | Waltenberger, J., et al. 1992. FEBS Lett. 313: 129-32. PMID: 1426279
- Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. | Usuki, K., et al. 1992. Biochem Biophys Res Commun. 184: 1311-6. PMID: 1590793
- Platelet-derived endothelial cell growth factor. | Heldin, CH., et al. 1991. J Cell Biochem. 47: 208-10. PMID: 1724243
- Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. | Ishikawa, F., et al. 1989. Nature. 338: 557-62. PMID: 2467210
- Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture. | Usuki, K., et al. 1989. Proc Natl Acad Sci U S A. 86: 7427-31. PMID: 2678104
- Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy. | Griffiths, L. and Stratford, IJ. 1997. Br J Cancer. 76: 689-93. PMID: 9310231
- Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13. | Stenman, G., et al. 1992. Cytogenet Cell Genet. 59: 22-3. PMID: 1733667
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD-ECGF Antibody (PGF-44C) | sc-47702 | 200 µg/ml | $316.00 | |||
PD-ECGF Antibody (PGF-44C): m-IgG Fc BP-HRP Bundle | sc-528508 | 200 µg Ab; 10 µg BP | $354.00 | |||
PD-ECGF Antibody (PGF-44C): m-IgGκ BP-HRP Bundle | sc-520902 | 200 µg Ab, 40 µg BP | $354.00 | |||
PD-ECGF Antibody (PGF-44C): m-IgG1 BP-HRP Bundle | sc-542966 | 200 µg Ab; 20 µg BP | $354.00 | |||
PD-ECGF Antibody (PGF-44C) AC | sc-47702 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PD-ECGF Antibody (PGF-44C) HRP | sc-47702 HRP | 200 µg/ml | $316.00 | |||
PD-ECGF Antibody (PGF-44C) FITC | sc-47702 FITC | 200 µg/ml | $330.00 | |||
PD-ECGF Antibody (PGF-44C) PE | sc-47702 PE | 200 µg/ml | $343.00 | |||
PD-ECGF Antibody (PGF-44C) Alexa Fluor® 488 | sc-47702 AF488 | 200 µg/ml | $357.00 | |||
PD-ECGF Antibody (PGF-44C) Alexa Fluor® 546 | sc-47702 AF546 | 200 µg/ml | $357.00 | |||
PD-ECGF Antibody (PGF-44C) Alexa Fluor® 594 | sc-47702 AF594 | 200 µg/ml | $357.00 | |||
PD-ECGF Antibody (PGF-44C) Alexa Fluor® 647 | sc-47702 AF647 | 200 µg/ml | $357.00 | |||
PD-ECGF Antibody (PGF-44C) Alexa Fluor® 680 | sc-47702 AF680 | 200 µg/ml | $357.00 | |||
PD-ECGF Antibody (PGF-44C) Alexa Fluor® 790 | sc-47702 AF790 | 200 µg/ml | $357.00 |