PD-ECGF Antibody (C-6): sc-515552

PD-ECGF Antibody (C-6) is a mouse monoclonal IgG1 antibody that detects platelet-derived endothelial cell growth factor (PD-ECGF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PD-ECGF, also known as thymidine phosphorylase or gliostatin, plays a crucial role in angiogenesis by stimulating endothelial cell proliferation and promoting chemotaxis, which is vital for the formation of new blood vessels. PD-ECGF is primarily located in platelets, placenta, foreskin fibroblasts, and various squamous cell carcinomas, where secretion occurs slowly, indicating potential involvement in both normal physiological processes and pathological conditions. Notably, PD-ECGF exists as a functional dimer composed of two polypeptide chains, and overexpression has been observed in tumor tissues and lesional psoriatic skin, suggesting a significant role in the pathophysiology of psoriasis. PD-ECGF′s structure is essential for function, as serine residues frequently associate with nucleotide triphosphates, including ATP, enabling catalysis of the reversible phosphorolysis of thymidine to thymine in an ATP-dependent manner, thereby exhibiting thymidine phosphorylase activity. With diverse applications and critical biological functions, anti-PD-ECGF antibody (C-6) serves as an invaluable tool for researchers studying angiogenesis and related diseases.

The preferred PD-ECGF antibody is PD-ECGF Antibody (PGF-44C): sc-47702.