PD-ECGF Antibody (0.N.568): sc-71867

PD-ECGF Antibody (0.N.568) is a mouse monoclonal IgG1 antibody that detects platelet-derived endothelial cell growth factor (PD-ECGF) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PD-ECGF, also known as thymidine phosphorylase or gliostatin, plays a crucial role in angiogenesis by stimulating endothelial cell growth and promoting chemotaxis, which is vital for tissue repair and regeneration. PD-ECGF exists as a functional dimer composed of two polypeptide chains, which are expressed in various tissues including platelets, placenta, foreskin fibroblasts, and certain squamous cell carcinomas, and are gradually secreted from these cells. Notably, PD-ECGF is overexpressed in tumor tissues and lesional psoriatic skin, suggesting involvement in the pathophysiology of psoriasis. PD-ECGF′s structure contains serine residues that are often associated with nucleotide triphosphates like ATP, enabling catalysis of the reversible phosphorolysis of thymidine to thymine in an ATP-dependent manner, thereby exhibiting thymidine phosphorylase activity. This enzymatic function highlights PD-ECGF′s role in nucleotide metabolism and underscores potential implications in cancer biology and therapeutic strategies targeting angiogenesis.

The preferred PD-ECGF antibody is PD-ECGF Antibody (PGF-44C): sc-47702.