PCSK1N Antibody (D-11): sc-398295
- PCSK1N Antibody (D-11) is a mouse monoclonal IgG1 κ PCSK1N antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 47-69 near the N-terminus of PCSK1N of mouse origin
- PCSK1N Antibody (D-11) is recommended for detection of PCSK1N of mouse and rat origin by WB, IP, IF and ELISA
- Anti-PCSK1N Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PCSK1N Antibody (D-11) for WB applications. This reagent is now offered in a bundle with PCSK1N Antibody (D-11) (see ordering information below).
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PCSK1N Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects PCSK1N protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PCSK1N (D-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PCSK1N protein, also known as proprotein convertase subtilisin/kexin type 1 inhibitor, is a 260 amino acid protein that plays a crucial role in regulating the neuroendocrine secretory pathway, particularly by inhibiting proprotein convertase 1 (PCSK1), which is essential for the processing of prohormones and neuropeptides. This inhibition is vital for maintaining proper hormonal balance and neuropeptide signaling, which can have significant implications for metabolic and neurological health. PCSK1N is expressed in both the pancreas and brain, and PCSK1N localization to the trans-Golgi network is important for function in protein processing and secretion. The gene encoding PCSK1N is located on human chromosome X, which is significant not only for its role in sex determination but also for its association with various genetic conditions when abnormalities occur in sex chromosome number or structure.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PCSK1N Antibody (D-11) References:
- Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. | Fricker, LD., et al. 2000. J Neurosci. 20: 639-48. PMID: 10632593
- Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1. | Basak, A., et al. 2001. J Biol Chem. 276: 32720-8. PMID: 11435430
- Functional characterization of ProSAAS: similarities and differences with 7B2. | Fortenberry, Y., et al. 2002. J Biol Chem. 277: 5175-86. PMID: 11719503
- An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. | Kikuchi, K., et al. 2003. Biochem Biophys Res Commun. 308: 646-54. PMID: 12914799
- A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. | Wada, M., et al. 2004. Neurosci Lett. 356: 49-52. PMID: 14746899
- Quantification of VGF- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress. | Chakraborty, TR., et al. 2006. Brain Res. 1089: 21-32. PMID: 16631141
- Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences. | Kudo, H., et al. 2009. Endocrinology. 150: 1393-9. PMID: 18948394
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCSK1N Antibody (D-11) | sc-398295 | 200 µg/ml | $322.00 | |||
PCSK1N Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-526305 | 200 µg Ab; 10 µg BP | $361.00 | |||
PCSK1N Antibody (D-11) AC | sc-398295 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PCSK1N Antibody (D-11) HRP | sc-398295 HRP | 200 µg/ml | $322.00 | |||
PCSK1N Antibody (D-11) FITC | sc-398295 FITC | 200 µg/ml | $336.00 | |||
PCSK1N Antibody (D-11) PE | sc-398295 PE | 200 µg/ml | $349.00 | |||
PCSK1N Antibody (D-11) Alexa Fluor® 488 | sc-398295 AF488 | 200 µg/ml | $364.00 | |||
PCSK1N Antibody (D-11) Alexa Fluor® 546 | sc-398295 AF546 | 200 µg/ml | $364.00 | |||
PCSK1N Antibody (D-11) Alexa Fluor® 594 | sc-398295 AF594 | 200 µg/ml | $364.00 | |||
PCSK1N Antibody (D-11) Alexa Fluor® 647 | sc-398295 AF647 | 200 µg/ml | $364.00 | |||
PCSK1N Antibody (D-11) Alexa Fluor® 680 | sc-398295 AF680 | 200 µg/ml | $364.00 | |||
PCSK1N Antibody (D-11) Alexa Fluor® 790 | sc-398295 AF790 | 200 µg/ml | $364.00 | |||
PCSK1N (D-11) Neutralizing Peptide | sc-398295 P | 100 µg/0.5 ml | $69.00 |