PCDHAC Antibody (2C1/E7): sc-130555
- PCDHAC Antibody (2C1/E7) is a mouse monoclonal IgG1 κ PCDHAC antibody provided at 200 µg/ml
- raised against a 152 amino acid sequence corresponding to the conserved C-terminal region of PCDHGC of mouse origin
- PCDHAC Antibody (2C1/E7) is recommended for detection of proteins containing the conserved C-terminal region of PCDHAC of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PCDHAC Antibody (2C1/E7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PCDHAC Antibody (2C1/E7) for WB applications. These reagents are now offered in bundles with PCDHAC Antibody (2C1/E7) (see ordering information below).
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PCDHAC Antibody (2C1/E7) is a mouse monoclonal IgG1 kappa light chain antibody that detects PCDHAC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDHAC antibody (2C1/E7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Protocadherins, including PCDHAC, play a crucial role in establishing and maintaining neuronal connections, vital for proper brain function and communication between neurons. PCDHAC protein belongs to a larger family of clustered protocadherins highly expressed in the nervous system and involved in synaptic recognition and adhesion. PCDHAC derives from the PCDHA gene cluster, consisting of 14 cadherin-related molecules exhibiting unique expression patterns regulated by individual promoters. PCDHAC genomic structure, located on chromosome 5, highlights significance in the serotonergic system through strong expression in serotonergic neurons, influencing neurotransmission and potentially impacting mood and behavior. Understanding PCDHAC function and interactions remains essential for elucidating roles in neurodevelopmental processes and implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PCDHAC Antibody (2C1/E7) References:
- The role and expression of the protocadherin-alpha clusters in the CNS. | Hirayama, T. and Yagi, T. 2006. Curr Opin Neurobiol. 16: 336-42. PMID: 16697637
- Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells. | Kaneko, R., et al. 2006. J Biol Chem. 281: 30551-60. PMID: 16893882
- Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster. | Kawaguchi, M., et al. 2008. J Biol Chem. 283: 12064-75. PMID: 18204046
- Clustered protocadherin family. | Yagi, T. 2008. Dev Growth Differ. 50 Suppl 1: S131-40. PMID: 18430161
- Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia. | Lachman, HM., et al. 2008. Psychiatr Genet. 18: 110-5. PMID: 18496207
- Inhibition of protocadherin-alpha function results in neuronal death in the developing zebrafish. | Emond, MR. and Jontes, JD. 2008. Dev Biol. 321: 175-87. PMID: 18602383
- Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. | Fukuda, E., et al. 2008. Eur J Neurosci. 28: 1362-76. PMID: 18973563
- Expression levels of Protocadherin-alpha transcripts are decreased by nonsense-mediated mRNA decay with frameshift mutations and by high DNA methylation in their promoter regions. | Kaneko, R., et al. 2009. Gene. 430: 86-94. PMID: 19038318
- Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas. | Katori, S., et al. 2009. J Neurosci. 29: 9137-47. PMID: 19625505
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCDHAC Antibody (2C1/E7) | sc-130555 | 200 µg/ml | $322.00 | |||
PCDHAC Antibody (2C1/E7): m-IgG Fc BP-HRP Bundle | sc-527085 | 200 µg Ab; 10 µg BP | $361.00 | |||
PCDHAC Antibody (2C1/E7): m-IgG1 BP-HRP Bundle | sc-532458 | 200 µg Ab; 20 µg BP | $361.00 | |||
PCDHAC Antibody (2C1/E7) AC | sc-130555 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PCDHAC Antibody (2C1/E7) HRP | sc-130555 HRP | 200 µg/ml | $322.00 | |||
PCDHAC Antibody (2C1/E7) FITC | sc-130555 FITC | 200 µg/ml | $336.00 | |||
PCDHAC Antibody (2C1/E7) PE | sc-130555 PE | 200 µg/ml | $349.00 | |||
PCDHAC Antibody (2C1/E7) Alexa Fluor® 488 | sc-130555 AF488 | 200 µg/ml | $364.00 | |||
PCDHAC Antibody (2C1/E7) Alexa Fluor® 546 | sc-130555 AF546 | 200 µg/ml | $364.00 | |||
PCDHAC Antibody (2C1/E7) Alexa Fluor® 594 | sc-130555 AF594 | 200 µg/ml | $364.00 | |||
PCDHAC Antibody (2C1/E7) Alexa Fluor® 647 | sc-130555 AF647 | 200 µg/ml | $364.00 | |||
PCDHAC Antibody (2C1/E7) Alexa Fluor® 680 | sc-130555 AF680 | 200 µg/ml | $364.00 | |||
PCDHAC Antibody (2C1/E7) Alexa Fluor® 790 | sc-130555 AF790 | 200 µg/ml | $364.00 |