PCDHA8 Antibody (A-9): sc-514530

PCDHA8 Antibody (A-9) is a mouse monoclonal IgM antibody that detects PCDHA8 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDHA8 antibody (A-9) is available as the non-conjugated form. Protocadherins, including PCDHA8, play a crucial role in establishing and maintaining neuronal connections in the brain, which is vital for proper neural function and communication. PCDHA8 is a single-pass type I membrane protein composed of 950 amino acids and features six cadherin domains, highlighting structural importance in mediating cell adhesion. Encoded by a gene located within the protocadherin alpha gene cluster on human chromosome 5, PCDHA8 exists in multiple alternatively spliced isoforms, suggesting a complex regulatory mechanism that may influence function in neuronal connectivity. As a potential calcium-dependent cell adhesion protein, PCDHA8 is essential for synapse formation and neural network architecture, making PCDHA8 a significant target for research in neurobiology and related fields.

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PCDHA8 Antibody (A-9) References:

1. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.  |  Wu, Q. and Maniatis, T. 2000. Proc Natl Acad Sci U S A. 97: 3124-9. PMID: 10716726
2. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.  |  Yagi, T. and Takeichi, M. 2000. Genes Dev. 14: 1169-80. PMID: 10817752
3. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.  |  Nollet, F., et al. 2000. J Mol Biol. 299: 551-72. PMID: 10835267
4. Recent progress in protocadherin research.  |  Suzuki, ST. 2000. Exp Cell Res. 261: 13-8. PMID: 11082270
5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.  |  Wu, Q., et al. 2001. Genome Res. 11: 389-404. PMID: 11230163
6. Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster.  |  Noonan, JP., et al. 2003. Am J Hum Genet. 72: 621-35. PMID: 12577201
7. Identification of long-range regulatory elements in the protocadherin-alpha gene cluster.  |  Ribich, S., et al. 2006. Proc Natl Acad Sci U S A. 103: 19719-24. PMID: 17172445

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PCDHA8 Antibody (A-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PCDHA8 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PCDHA8 Antibody (A-9) Specifications

Alternate Product Name: PCDHA8

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 573-588

Epitope Target: PCDHA8

Epitope Species: rat

Product Reactivity/Detection: PCDHA8

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PCDHA8 Antibody (A-9): P: Blocking Peptide