PCB Antibody (B-6): sc-271862
- PCB Antibody (B-6) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 127-153 near the N-terminus of PCB of human origin
- recommended for detection of PCB of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PCB Antibody (B-6) for WB applications. These reagents are now offered in bundles with PCB Antibody (B-6) (see ordering information below).
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PCB Antibody (B-6) is a mouse monoclonal IgG2a antibody that detects pyruvate carboxylase (PCB) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PCB (B-6) monoclonal antibody plays a crucial role in studying pyruvate carboxylase, a biotinylated mitochondrial enzyme essential for the synthesis of oxaloacetate from pyruvate, which is a key step in gluconeogenesis and anaplerotic pathways. Anti-PCB antibody (B-6) enables research into pyruvate carboxylase function, which is vital for maintaining metabolic homeostasis, as deficiencies can lead to severe metabolic disorders, including lactic acidosis and hypoglycemia, which can have significant neurological implications. PCB (B-6) antibody supports studies of pyruvate carboxylase within mitochondria, highlighting its importance in energy metabolism and direct connection to carbohydrate metabolism and the citric acid cycle. PCB monoclonal antibody (B-6) facilitates research into pyruvate carboxylase interactions with other proteins, such as acetyl-CoA and ATP, helping elucidate regulatory mechanisms and potential therapeutic targets in metabolic diseases.
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PCB Antibody (B-6) References:
- Pyruvate carboxylase in genetic obesity. | Lynch, CJ., et al. 1992. Am J Physiol. 262: E608-18. PMID: 1375435
- Distribution of pyruvate carboxylase along the rat nephron: an immunological and enzymatic study. | Salto, R., et al. 1991. Kidney Int. 39: 1162-7. PMID: 1895670
- Electron microscopic localization of pyruvate carboxylase in rat liver and Saccharomyces cerevisiae by immunogold procedures. | Rohde, M., et al. 1991. Arch Biochem Biophys. 290: 197-201. PMID: 1898090
- The presence of pyruvate carboxylase in the human brain and its role in the survival of cultured human astrocytes. | Gondáš, E., et al. 2023. Physiol Res. 72: 403-414. PMID: 37449752
- Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. | Shank, RP., et al. 1985. Brain Res. 329: 364-7. PMID: 3884090
- Immunochemical studies with soluble and mitochondrial pyruvate carboxylase activities from rat tissues. | Ballard, FJ., et al. 1970. Biochem J. 119: 735-42. PMID: 5493507
- Regulation of the synthesis and degradation of pyruvate carboxylase in 3T3-L1 cells. | Freytag, SO. and Utter, MF. 1983. J Biol Chem. 258: 6307-12. PMID: 6343373
- Characterization of the subunit structure of pyruvate carboxylase from Pseudomonas citronellolis. | Goss, JA., et al. 1981. J Biol Chem. 256: 11819-25. PMID: 6795193
- Induction of pyruvate carboxylase apoenzyme and holoenzyme in 3T3-L1 cells during differentiation. | Freytag, SO. and Utter, MF. 1980. Proc Natl Acad Sci U S A. 77: 1321-5. PMID: 6929488
- Pyruvate carboxylase and phosphoenopyruvate carboxykinase in cultured human fibroblasts. | Raghunathan, R., et al. 1977. J Cell Physiol. 92: 285-92. PMID: 881436
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCB Antibody (B-6) | sc-271862 | 200 µg/ml | $316.00 | |||
PCB Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-540268 | 200 µg Ab; 10 µg BP | $354.00 | |||
PCB Antibody (B-6): m-IgG2a BP-HRP Bundle | sc-546879 | 200 µg Ab; 10 µg BP | $354.00 | |||
PCB (B-6) Neutralizing Peptide | sc-271862 P | 100 µg/0.5 ml | $68.00 |