PC-1 Antibody (F-8): sc-166649

PC-1 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects PC-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PC-1, also known as ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) or membrane component, chromosome 6, surface marker-1 (M6S1), is a homodimeric protein primarily expressed in plasma cells, but is also found in hepatocytes, renal tubules, salivary duct epithelium, epididymis, capillary endothelium in the brain, and chondrocytes. PC-1 plays a crucial role in regulating nucleotide metabolism and has been implicated in the pathophysiology of insulin resistance, particularly in non-insulin-dependent diabetes mellitus (NIDDM). PC-1 (F-8) antibody helps researchers study how PC-1 interacts directly with the insulin receptor α subunit, which may contribute to insulin resistance observed in many patients with NIDDM. PC-1 encoding gene is located on human chromosome 6q22-q23, a region frequently associated with deletions in lymphoid neoplasia, highlighting PC-1′s potential significance in both metabolic and oncological contexts. Anti-PC-1 antibody (F-8) serves as an essential tool for researchers investigating molecular mechanisms underlying insulin resistance and related metabolic disorders.

The preferred PC-1 antibody is PC-1 Antibody (H-7): sc-393419.