Pbx 3a Antibody (2.9): sc-101854

Pbx 3a Antibody (2.9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pbx 3a in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Pbx 3a antibody (2.9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pbx 3a is a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, which play crucial roles in regulating gene expression during development and differentiation. Pbx 3a (2.9) monoclonal antibody recognizes protein complexes that interact with other transcription factors, such as E2A proteins, which are essential for hematopoiesis and lymphocyte development. The interaction between Pbx 3a and E2A is particularly significant in human pre-B cell acute leukemias, where chromosomal rearrangements can lead to fusion proteins that disrupt normal cellular functions. Pbx 3a shares high sequence identity with Pbx 1 and Pbx 2, indicating a conserved functional role within the family, while also demonstrating unique expression patterns that suggest specialized functions in various tissues. Ubiquitous expression of Pbx genes in both fetal and adult tissues underscores their importance in maintaining cellular homeostasis and regulating developmental processes.

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Pbx 3a Antibody (2.9) References:

1. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.  |  Toresson, H., et al. 2000. Mech Dev. 94: 183-7. PMID: 10842069
2. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.  |  Wagner, K., et al. 2001. Mech Dev. 103: 127-31. PMID: 11335119
3. Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities.  |  Milech, N., et al. 2001. Genes Chromosomes Cancer. 32: 275-80. PMID: 11579467
4. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.  |  Monica, K., et al. 1991. Mol Cell Biol. 11: 6149-57. PMID: 1682799
5. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.  |  Nourse, J., et al. 1990. Cell. 60: 535-45. PMID: 1967982
6. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.  |  Kamps, MP., et al. 1990. Cell. 60: 547-55. PMID: 1967983
7. P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways.  |  He, X., et al. 2023. Leukemia. 37: 265-275. PMID: 36418376
8. PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression.  |  Luo, X., et al. 2023. Int J Biol Sci. 19: 4525-4538. PMID: 37781025
9. A 5.4-Mb continuous pulsed-field gel electrophoresis map of human 9q34.1 between ABL and D9S114, including the tuberous sclerosis (TSC1) region.  |  Henske, EP. and Kwiatkowski, DJ. 1995. Genomics. 28: 105-8. PMID: 7590733
10. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.  |  Lu, Q., et al. 1994. Mol Cell Biol. 14: 3938-48. PMID: 7910944
11. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.  |  Monica, K., et al. 1994. Mol Cell Biol. 14: 8304-14. PMID: 7969166
12. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.  |  LeBrun, DP. and Cleary, ML. 1994. Oncogene. 9: 1641-7. PMID: 8183558

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pbx 3a Antibody (2.9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Pbx 3a Antibody (2.9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pbx 3a Antibody (2.9) Specifications

Alternate Product Name: Pbx 3a

Product Clone Name: 2.9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 352-432

Epitope Target: Pbx 3a

Epitope Species: mouse

Product Reactivity/Detection: Pbx 3a

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Pbx 3a Antibody (2.9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Pbx 1/2/3/4 antibody is Pbx 1/2/3/4 Antibody (F-3): sc-28313.