Pbx 1a Antibody (710.2): sc-101851

Pbx 1a Antibody (710.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pbx 1a protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Pbx 1a antibody (710.2) is available as non-conjugated format. Pbx 1a is a crucial member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, which play significant roles in regulating gene expression during development and differentiation. Pbx 1a forms protein complexes that interact with other transcription factors, such as E2A, particularly important in human pre-B cell acute leukemias where chromosomal rearrangement can lead to fusion gene creation. This interaction regulates hematopoiesis and B cell development. Pbx 1a shows ubiquitous expression across various tissues, underscoring essential functions in both fetal and adult stages. Alternative splicing forms of Pbx 1 and Pbx 3, which differ in carboxy-termini, add complexity to regulatory roles, making Pbx 1a a significant target for research in developmental biology and cancer studies.

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Pbx 1a Antibody (710.2) References:

1. The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells.  |  Thorsteinsdottir, U., et al. 1999. Mol Cell Biol. 19: 6355-66. PMID: 10454582
2. Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.  |  Toresson, H., et al. 2000. Mech Dev. 94: 183-7. PMID: 10842069
3. A conformational change in PBX1A is necessary for its nuclear localization.  |  Saleh, M., et al. 2000. Exp Cell Res. 260: 105-15. PMID: 11010815
4. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.  |  Wagner, K., et al. 2001. Mech Dev. 103: 127-31. PMID: 11335119
5. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.  |  Monica, K., et al. 1991. Mol Cell Biol. 11: 6149-57. PMID: 1682799
6. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.  |  Nourse, J., et al. 1990. Cell. 60: 535-45. PMID: 1967982
7. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.  |  Kamps, MP., et al. 1990. Cell. 60: 547-55. PMID: 1967983
8. The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.  |  Sgadò, P., et al. 2012. Neural Dev. 7: 24. PMID: 22748019
9. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.  |  Lu, Q., et al. 1994. Mol Cell Biol. 14: 3938-48. PMID: 7910944
10. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.  |  Monica, K., et al. 1994. Mol Cell Biol. 14: 8304-14. PMID: 7969166
11. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.  |  LeBrun, DP. and Cleary, ML. 1994. Oncogene. 9: 1641-7. PMID: 8183558
12. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target.  |  Shen, WF., et al. 1997. J Biol Chem. 272: 8198-206. PMID: 9079637

The preferred Pbx 1b antibody is Pbx 1b Antibody (41.1): sc-101852.