PBP Antibody (C-24): sc-73636

PBP Antibody (C-24) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PBP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). PBP (C-24) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. The platelet basic protein (PBP) is a crucial member of the alpha-chemokine family, primarily located in the alpha-granules of platelets, where PBP plays a significant role in mediating inflammatory responses and wound healing. Upon platelet activation, PBP is released and undergoes proteolytic cleavage, resulting in several biologically active peptides, including mature PBP, connective tissue-activating peptide III (CTAP III), beta-thromboglobulin, and neutrophil-activating peptide 2 (NAP-2). NAP-2 is instrumental in activating neutrophils, promoting chemotaxis and degranulation during inflammatory processes, which underscores PBP′s importance in immune response and tissue repair. The gene encoding human PBP is located on chromosome 4q12-q13, highlighting PBP′s genetic significance in human health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PBP Antibody (C-24) References:

1. Down-regulation of neutrophil functions by the ELR(+) CXC chemokine platelet basic protein.  |  Ehlert, JE., et al. 2000. Blood. 96: 2965-72. PMID: 11049972
2. Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.  |  Wenger, RH., et al. 1991. Hum Genet. 87: 367-8. PMID: 1830861
3. Formation of neutrophil-activating peptide 2 from platelet-derived connective-tissue-activating peptide III by different tissue proteinases.  |  Car, BD., et al. 1991. Biochem J. 275 (Pt 3): 581-4. PMID: 2039437
4. Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.  |  Holt, JC., et al. 1986. Biochemistry. 25: 1988-96. PMID: 2423119
5. CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.  |  Hoogewerf, AJ., et al. 1995. J Biol Chem. 270: 3268-77. PMID: 7852412
6. The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence.  |  Malkowski, MG., et al. 1997. J Mol Biol. 266: 367-80. PMID: 9047370
7. Structure and bioactivity of recombinant human CTAP-III and NAP-2.  |  Proudfoot, AE., et al. 1997. J Protein Chem. 16: 37-49. PMID: 9055206

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PBP Antibody (C-24) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PBP Antibody (C-24) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PBP Antibody (C-24) Specifications

Alternate Product Name: PBP

Product Clone Name: C-24

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PBP

Epitope Species: human

Product Reactivity/Detection: PBP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PBP Antibody (C-24): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin