PBK Antibody (31): sc-136026
- PBK Antibody (31) is a mouse monoclonal IgG2b, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 191-322 of PBK of human origin
- recommended for detection of PBK of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PBK Antibody (31). This work is in progress.
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SEE ALSO...
PBK Antibody (31) is a mouse monoclonal IgG2b antibody that detects PBK in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). PBK, or human PDZ-binding kinase, is a crucial serine/threonine kinase composed of 322 amino acids, characterized by its T/SXV motif, which plays a significant role in regulating cellular processes. PBK is predominantly found in the placenta and is notably absent in adult brain tissue, highlighting its specialized function in reproductive biology. The presence of a PDZ domain in the tumor suppressor protein Dlg allows for interaction with the T/SXV motif of PBK, suggesting a potential regulatory mechanism in cell signaling pathways. Furthermore, PBK is activated by the cell cycle checkpoint kinase Cdc2/cyclin B, which phosphorylates PBK, thereby influencing its activity. The active form of PBK can associate with PDZ-containing proteins, thereby impacting cell cycle control and cellular proliferation, making PBK an important target for studies related to cancer and developmental biology. Anti-PBK antibody (31) is an essential tool for researchers investigating the intricate roles of PBK in various biological processes and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PBK Antibody (31) | sc-136026 | 50 µg/0.5 ml | $322.00 |