PAXX Antibody (E-4): sc-514359
- PAXX Antibody (E-4) is a mouse monoclonal IgG2b κ PAXX antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 22-41 near the N-terminus of PAXX of human origin
- PAXX Antibody (E-4) is recommended for detection of PAXX of human origin by WB, IP, IF and ELISA
- Anti-PAXX Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PAXX Antibody (E-4) for WB applications. These reagents are now offered in bundles with PAXX Antibody (E-4) (see ordering information below).
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PAXX Antibody (E-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects PAXX protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PAXX antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PAXX plays a crucial role in the DNA damage response, particularly in the repair of double-strand breaks through involvement in the non-homologous end joining pathway. This function is vital for maintaining genomic stability, as failure to properly repair DNA can lead to mutations, cancer, and other genetic disorders. PAXX interacts with other key proteins involved in DNA repair, such as XRCC4 and DNA ligase IV, highlighting importance in the cellular response to DNA damage. Understanding PAXX′s role in these processes can provide insights into potential therapeutic targets for cancer treatment and the development of strategies to enhance DNA repair mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PAXX Antibody (E-4) References:
- DNA sequence and analysis of human chromosome 9. | Humphray, SJ., et al. 2004. Nature. 429: 369-74. PMID: 15164053
- BCR-ABL activates STAT3 via JAK and MEK pathways in human cells. | Coppo, P., et al. 2006. Br J Haematol. 134: 171-9. PMID: 16846476
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. | Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
- Gene expression fingerprinting for human hereditary hemorrhagic telangiectasia. | Fernandez-L, A., et al. 2007. Hum Mol Genet. 16: 1515-33. PMID: 17420163
- Phenotypic and cytogenetic spectrum of 9p trisomy. | Temtamy, SA., et al. 2007. Genet Couns. 18: 29-48. PMID: 17515299
- Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. | Gardiner, J., et al. 2007. Traffic. 8: 1145-9. PMID: 17605759
- Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). | Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
- A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect. | Hims, MM., et al. 2007. Genomics. 90: 389-96. PMID: 17644305
- Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia. | Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAXX Antibody (E-4) | sc-514359 | 200 µg/ml | $316.00 | |||
PAXX Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-524695 | 200 µg Ab, 40 µg BP | $354.00 | |||
PAXX Antibody (E-4): m-IgG2b BP-HRP Bundle | sc-549175 | 200 µg Ab; 10 µg BP | $354.00 | |||
PAXX Antibody (E-4) AC | sc-514359 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PAXX Antibody (E-4) HRP | sc-514359 HRP | 200 µg/ml | $316.00 | |||
PAXX Antibody (E-4) FITC | sc-514359 FITC | 200 µg/ml | $330.00 | |||
PAXX Antibody (E-4) PE | sc-514359 PE | 200 µg/ml | $343.00 | |||
PAXX Antibody (E-4) Alexa Fluor® 488 | sc-514359 AF488 | 200 µg/ml | $357.00 | |||
PAXX Antibody (E-4) Alexa Fluor® 546 | sc-514359 AF546 | 200 µg/ml | $357.00 | |||
PAXX Antibody (E-4) Alexa Fluor® 594 | sc-514359 AF594 | 200 µg/ml | $357.00 | |||
PAXX Antibody (E-4) Alexa Fluor® 647 | sc-514359 AF647 | 200 µg/ml | $357.00 | |||
PAXX Antibody (E-4) Alexa Fluor® 680 | sc-514359 AF680 | 200 µg/ml | $357.00 | |||
PAXX Antibody (E-4) Alexa Fluor® 790 | sc-514359 AF790 | 200 µg/ml | $357.00 | |||
PAXX (E-4) Neutralizing Peptide | sc-514359 P | 100 µg/0.5 ml | $68.00 |