Pax-7 Antibody (EE-8): sc-81975

Pax-7 Antibody (EE-8) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect the Pax-7 protein, also known as PAX7, a critical member of the paired box (PAX) family of nuclear transcription factors. Pax-7 monoclonal antibody (EE-8) is raised against recombinant human Pax-7 and exhibits strong reactivity with Pax-7 from mouse, rat, and human origins, making anti-Pax-7 antibody (EE-8) suitable for various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Pax-7 is predominantly located in the nucleus of satellite cells and myoblasts, where Pax-7 plays a vital role in regulating gene expression essential for the differentiation and maintenance of muscle tissue. The precise nuclear localization of Pax-7 is crucial for Pax-7′s function in controlling the proliferation and self-renewal of muscle stem cells, which is important for muscle regeneration and repair. Additionally, Pax-7 is involved in multiple signal transduction pathways that influence cellular differentiation during embryogenesis and in adult organisms. Mutations and chromosomal aberrations in the PAX7 gene have been implicated in various diseases, including rhabdomyosarcoma type 2 (RMS2), also known as alveolar rhabdomyosarcoma, highlighting Pax-7′s significance in cancer research. Available in a non-conjugated form, Pax-7 (EE-8) antibody provides researchers with a reliable tool to investigate the expression, localization, and functional roles of Pax-7 in muscle biology and related pathological conditions. By targeting this key transcription factor, scientists can gain deeper insights into the molecular mechanisms governing muscle development, regeneration, and the progression of muscle-related diseases.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pax-7 Antibody (EE-8) has 21 citations in a variety of scientific publications.

Primary antibodies like Anti-Pax-7 Antibody (EE-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pax-7 Antibody (EE-8) Specifications

Alternate Product Name: Pax-7

Product Clone Name: EE-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 411-521

Epitope Target: Pax-7

Epitope Species: human

Product Reactivity/Detection: Pax-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 21 citations in various scientific publications

Available Conjugates/Forms for Pax-7 Antibody (EE-8): N/A

The preferred Pax-7 antibody is Pax-7 Antibody (PAX7): sc-81648.