Pax-5 Antibody (E-9): sc-55515
- Pax-5 Antibody (E-9) is a mouse monoclonal IgG2b λ, cited in 8 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 371-390 at the C-terminus of Pax-5 of human origin
- recommended for detection of Pax-5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- See Pax-5 (A-11): sc-13146 for Pax-5 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Pax-5 Antibody (E-9) for WB applications. This reagent is now offered in a bundle with Pax-5 Antibody (E-9) (see ordering information below).
Pax-5 Antibody (E-9) is a mouse monoclonal IgG2b antibody that detects Pax-5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pax-5 monoclonal antibody (E-9) recognizes a crucial member of the Pax family of nuclear transcription factors, playing a significant role in the regulation of B cell development and differentiation. Pax-5 is primarily located in the nucleus of B lymphocytes, where anti-Pax-5 antibody (E-9) confirms its role as a transcriptional activator, influencing the expression of genes essential for B cell lineage commitment. Proper localization of Pax-5 within the nucleus is vital for function, ensuring effective interaction with DNA and other transcriptional machinery to regulate gene expression. Dysregulation of Pax-5, often due to mutations or aberrant expression, can lead to severe consequences, including the development of various hematological malignancies, such as small lymphocytic lymphomas. Pax-5 (E-9) antibody serves as an invaluable tool for researchers studying B cell biology and the molecular mechanisms underlying related diseases, providing insights into the intricate signaling pathways that govern immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Pax-5 Antibody (E-9) References:
- Roles of EBF and Pax-5 in B lineage commitment and development. | Maier, H. and Hagman, J. 2002. Semin Immunol. 14: 415-22. PMID: 12457614
- Pax-5 protein expression in bladder cancer: a preliminary study that shows no correlation to grade, stage or clinical outcome. | Denzinger, S., et al. 2008. Pathology. 40: 465-9. PMID: 18604731
- Pax-5 is a potent regulator of E-cadherin and breast cancer malignant processes. | Benzina, S., et al. 2017. Oncotarget. 8: 12052-12066. PMID: 28076843
- The Pleiotropy of PAX5 Gene Products and Function. | Nasri Nasrabadi, P., et al. 2022. Int J Mol Sci. 23: PMID: 36077495
- PAX5 fusion genes in acute lymphoblastic leukemia: A literature review. | Fouad, FM. and Eid, JI. 2023. Medicine (Baltimore). 102: e33836. PMID: 37335685
- TIGIT-Fc fusion protein alleviates murine lupus nephritis through the regulation of SPI-B-PAX5-XBP1 axis-mediated B-cell differentiation. | Zhao, J., et al. 2023. J Autoimmun. 139: 103087. PMID: 37481835
- Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development. | Gruenbacher, S., et al. 2023. J Exp Med. 220: PMID: 37725138
- SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5. | Qi, J., et al. 2024. Proc Natl Acad Sci U S A. 121: e2314619121. PMID: 38776375
- A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5. | Gamez-Garcia, A., et al. 2024. Nat Immunol. 25: 2308-2319. PMID: 39424985
- Essential functions of Pax-5 (BSAP) in pro-B cell development. | Nutt, SL., et al. 1997. Immunobiology. 198: 227-35. PMID: 9442394
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pax-5 Antibody (E-9) | sc-55515 | 200 µg/ml | $316.00 | |||
Pax-5 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-539022 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pax-5 (E-9) Neutralizing Peptide | sc-55515 P | 100 µg/0.5 ml | $68.00 |