PAT2 Antibody (F-3): sc-390969

PAT2 Antibody (F-3) is a mouse monoclonal IgM antibody that detects PAT2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PAT2 antibody (F-3) is available as a non-conjugated format. PAT2 is a member of the proton-coupled amino acid transporter family, which plays a crucial role in the transport of small neutral amino acids and derivatives across cellular membranes. PAT2 is highly expressed in the spinal cord and brain, where PAT2 facilitates the uptake of essential amino acids, thereby influencing neurotransmitter synthesis and overall neuronal function. This transport activity is vital for maintaining amino acid homeostasis in the central nervous system, which is essential for proper brain function and development. PAT2′s ability to mediate the symport of protons and amino acids underscores its importance in cellular metabolism and signaling pathways. Additionally, the PAT family, including PAT2, is characterized by the presence of three conserved histidine residues, with His-55 being critical for the catalytic activity of its family members. This highlights the intricate structure-function relationship within the PAT family, making PAT2 a significant target for research in neurobiology and pharmacology.

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PAT2 Antibody (F-3) References:

1. The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis.  |  Boll, M., et al. 2004. Pflugers Arch. 447: 776-9. PMID: 12748860
2. A cluster of proton/amino acid transporter genes in the human and mouse genomes.  |  Boll, M., et al. 2003. Genomics. 82: 47-56. PMID: 12809675
3. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1.  |  Rubio-Aliaga, I., et al. 2004. J Biol Chem. 279: 2754-60. PMID: 14600155
4. Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2.  |  Foltz, M., et al. 2004. Eur J Biochem. 271: 3340-7. PMID: 15291811
5. Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells.  |  Metzner, L. and Brandsch, M. 2006. Eur J Pharm Biopharm. 63: 360-4. PMID: 16531028
6. Substrate specificity of the amino acid transporter PAT1.  |  Metzner, L., et al. 2006. Amino Acids. 31: 111-7. PMID: 16699824
7. Deciphering the mechanisms of intestinal imino (and amino) acid transport: the redemption of SLC36A1.  |  Thwaites, DT. and Anderson, CM. 2007. Biochim Biophys Acta. 1768: 179-97. PMID: 17123464
8. Mutational analysis of histidine residues in the human proton-coupled amino acid transporter PAT1.  |  Metzner, L., et al. 2008. Biochim Biophys Acta. 1778: 1042-50. PMID: 18230330

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PAT2 Antibody (F-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-PAT2 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PAT2 Antibody (F-3) Specifications

Alternate Product Name: PAT2

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1-50

Epitope Target: PAT2

Epitope Species: mouse

Product Reactivity/Detection: PAT2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for PAT2 Antibody (F-3): N/A