PARD6B Antibody (F-5): sc-390937
- PARD6B Antibody (F-5) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 309-372 mapping at the C-terminus of PARD6B of human origin
- recommended for detection of PARD6B of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PARD6B Antibody (F-5) for WB applications. This reagent is now offered in a bundle with PARD6B Antibody (F-5) (see ordering information below).
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PARD6B Antibody (F-5) is a mouse monoclonal IgG2a antibody that detects PARD6B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PARD6B, also known as PAR-6β, is a crucial component of the cell polarity machinery, playing a significant role in establishing and maintaining cellular asymmetry, which is vital for proper tissue organization and function. Anti-PARD6B antibody (F-5) recognizes PARD6B primarily at the cell membrane, where PARD6B interacts with other polarity proteins, including PARD3 and atypical protein kinase C isoforms, to form complexes essential for tight junction formation in epithelial cells. PARD6B localization at the cell periphery coordinates signaling pathways that dictate cell shape and polarity, thereby influencing processes such as cell division and differentiation. PARD6B is expressed in various tissues, including the pancreas, kidney, and brain, highlighting PARD6B′s importance in both normal physiology and potential implications in diseases such as cancer, where disruption of cell polarity can lead to tumorigenesis. PARD6B monoclonal antibody (F-5) serves as an invaluable tool for researchers studying cell polarity mechanisms and their implications in health and disease.
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PARD6B Antibody (F-5) References:
- Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator. | Labhart, P., et al. 2005. Proc Natl Acad Sci U S A. 102: 1339-44. PMID: 15677324
- More targets, more pathways and more clues for mutant p53. | Garritano, S., et al. 2013. Oncogenesis. 2: e54. PMID: 23817466
- Association between DNA methylation and multidrug resistance in human glioma SHG-44 cells. | Chen, J., et al. 2015. Mol Med Rep. 11: 43-52. PMID: 25333456
- Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. | Zhang, X., et al. 2016. Nat Genet. 48: 176-82. PMID: 26656844
- Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. | Saito, Y., et al. 2018. Biochim Biophys Acta Rev Cancer. 1869: 103-116. PMID: 29369778
- ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development. | Wang, H., et al. 2019. Cell Rep. 27: 2335-2353.e6. PMID: 31116980
- 3, 3', 5-Triiodo-L-thyronine affects polarity proteins of bovine Sertoli cells via WT1/non-canonical Wnt signaling pathway. | Wang, X., et al. 2020. Theriogenology. 148: 8-17. PMID: 32126395
- Identification of key modules and genes associated with breast cancer prognosis using WGCNA and ceRNA network analysis. | Yin, X., et al. 2020. Aging (Albany NY). 13: 2519-2538. PMID: 33318294
- Integrative multi-omics analysis reveals ortho-topolin riboside exhibits anticancer activity by regulating metabolic pathways in radio-resistant triple negative breast cancer cells. | Ahn, J., et al. 2024. Chem Biol Interact. 398: 111089. PMID: 38823535
- Identification of genes predicting chemoresistance and short survival in ovarian cancer. | Wang, C., et al. 2024. Transl Cancer Res. 13: 4354-4371. PMID: 39262489
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PARD6B Antibody (F-5) | sc-390937 | 200 µg/ml | $316.00 | |||
PARD6B Antibody (F-5): m-IgG Fc BP-HRP Bundle | sc-540873 | 200 µg Ab; 10 µg BP | $354.00 |