Pancreasin Antibody (D-5): sc-166764

Pancreasin Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Pancreasin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pancreasin (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Pancreasin protein, also known as marapsin (MPN) or channel activating protease 2-like protein (CAPH2), is a secreted pancreatic serine peptidase that plays a crucial role in the cleavage of peptides after arginine residues, which is essential for various biological processes such as cell growth and migration. Pancreasin is N-glycosylated and is involved in important physiological functions, including receptor activation and tissue remodeling. Notably, Pancreasin interacts with other serine proteases like prostatin, Tryptase-γ, Testisin, and Tryptase-ε, sharing approximately 40% amino acid identity with Tryptase-α and Tryptase-β. These interactions highlight Pancreasin′s significance in the serine protease family, where the presence of cysteine residues allows for the formation of disulfide bonds that are critical for maintaining structural integrity. Additionally, Pancreasin′s unique features, such as the absence of a C-terminal membrane anchor found in other related proteins, further emphasize its specialized role in the pancreatic environment.

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Pancreasin Antibody (D-5) References:

1. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.  |  Bhagwandin, VJ., et al. 2003. J Biol Chem. 278: 3363-71. PMID: 12441343
2. Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney.  |  Verghese, GM., et al. 2004. Am J Respir Cell Mol Biol. 30: 519-29. PMID: 12959947
3. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.  |  Tong, Z., et al. 2004. Am J Physiol Lung Cell Mol Physiol. 287: L928-35. PMID: 15246975
4. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.  |  Yasuda, S., et al. 2005. Blood. 105: 3893-901. PMID: 15701722
5. Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases.  |  Wong, GW. and Stevens, RL. 2005. Biochem Biophys Res Commun. 336: 579-84. PMID: 16143303
6. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain.  |  Cal, S., et al. 2006. BMC Biochem. 7: 9. PMID: 16566820
7. Serial analysis of gene expression (SAGE) in the rat limbal and central corneal epithelium.  |  Adachi, W., et al. 2006. Invest Ophthalmol Vis Sci. 47: 3801-10. PMID: 16936091
8. Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.  |  Stevens, RL. and Adachi, R. 2007. Immunol Rev. 217: 155-67. PMID: 17498058

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pancreasin Antibody (D-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Pancreasin Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pancreasin Antibody (D-5) Specifications

Alternate Product Name: Pancreasin

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 93-133

Epitope Target: Pancreasin

Epitope Species: human

Product Reactivity/Detection: Pancreasin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Pancreasin Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin