pan-Cytokeratin Antibody (7H8C4): sc-81703

pan-Cytokeratin Antibody (7H8C4) is a mouse monoclonal IgG1 antibody that detects pan-Cytokeratin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. pan-Cytokeratin is a crucial component of the cytoskeleton in epithelial cells, providing structural support and playing a significant role in maintaining cellular integrity and function. pan-Cytokeratin (7H8C4) antibody targets proteins primarily located in the cytoplasm, where pan-Cytokeratin forms a network of intermediate filaments that contribute to the mechanical resilience of epithelial tissues. This structural role helps protect cells from mechanical stress and contributes to the overall architecture of tissues, which is particularly important in organs that experience significant physical forces, such as the skin and the lining of the gastrointestinal tract. Additionally, pan-Cytokeratin serves as a valuable biomarker for identifying and characterizing various epithelial-derived tumors, as expression patterns can indicate the differentiation status of malignant cells. Specific cytokeratin isoforms are often upregulated in certain carcinomas, making anti-pan-Cytokeratin antibody (7H8C4) an essential tool for researchers and clinicians in the study of cancer biology and tissue pathology.

The preferred pan-Cytokeratin antibody is pan-Cytokeratin Antibody (C11): sc-8018.