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pan CEA Antibody (B-1): sc-398456

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  • pan CEA Antibody (B-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 106-139 within an internal region of CEACAM5 of human origin
  • recommended for detection of a broad range of CEACAM family members of human origin by WB, IP, IF and ELISA
  • m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pan CEA Antibody (B-1) for WB applications. These reagents are now offered in bundles with pan CEA Antibody (B-1) (see ordering information below).
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    pan CEA Antibody (B-1) is a mouse monoclonal IgG2b antibody that detects carcinoembryonic antigen (CEA) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Carcinoembryonic antigen plays a crucial role in cell adhesion and signaling, which is vital for maintaining tissue architecture and facilitating communication between cells. CEA is primarily located on the cell surface, where CEA participates in various cellular processes, including the regulation of immune responses and the promotion of tumor progression. CEA presence in serum is often associated with certain types of cancer, making CEA an important biomarker for diagnosis and monitoring treatment efficacy. anti-CEA antibody (B-1) provides reliable detection of CEA, enabling researchers to explore CEA functions and interactions in both normal and pathological states, thereby contributing to a deeper understanding of cancer biology and potential therapeutic targets.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    pan CEA Antibody (B-1) References:

    1. Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice.  |  Saha, A., et al. 2004. Cancer Res. 64: 4995-5003. PMID: 15256474
    2. Preparation of carcinoembryonic antigen (CEA) containing significantly increased amounts of galactose and galactosamine.  |  Joung, JI., et al. 1975. Prep Biochem. 5: 359-74. PMID: 171642
    3. Enhancement of carcinoembryonic antigen (CEA) expression in colorectal tumors by neuraminidase.  |  Dejica, DI., et al. 1991. Roum Arch Microbiol Immunol. 50: 199-207. PMID: 1726506
    4. Immunological characteristics of monoclonal antibodies against human carcinoembryonic antigen (CEA).  |  Tsai, LC., et al. 1985. Proc Natl Sci Counc Repub China B. 9: 287-97. PMID: 2419936
    5. Interconversion between two electrophoretic forms of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA).  |  Krop-Watorek, A., et al. 1989. Arch Immunol Ther Exp (Warsz). 37: 703-14. PMID: 2487380
    6. Diagnostic usefulness of plasma carcinoembryonic antigen (CEA) levels in Crohn's disease.  |  Meryn, S. and Lochs, H. 1983. Dig Dis Sci. 28: 478-9. PMID: 6839911
    7. Circulating carcinoembryonic antigen (CEA), a growth parameter in malignant disease.  |  Staab, HJ. and Anderer, FA. 1983. Cancer Detect Prev. 6: 33-9. PMID: 6883391
    8. Carcinoembryonic antigen (CEA): its role as a monitor of radiation therapy for colorectal cancer.  |  Sugarbaker, PH., et al. 1978. Cancer. 42: 1434-6. PMID: 709512
    9. The carcinoembryonic antigen of the digestive system (CEA) and the antigens cross-reacting with it.  |  Burtin, P. 1978. Ann Immunol (Paris). 129: 185-98. PMID: 79326
    10. Heterogeneity of carcinoembryonic antigen. I. Concanavalin A-reactive and -nonreactive CEA.  |  Kosaki, G. and Yamamoto, T. 1975. Ann N Y Acad Sci. 259: 366-76. PMID: 812411

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    pan CEA Antibody (B-1)

    sc-398456
    200 µg/ml
    $322.00

    pan CEA Antibody (B-1): m-IgGκ BP-HRP Bundle

    sc-536063
    200 µg Ab; 40 µg BP
    $361.00

    pan CEA Antibody (B-1): m-IgG2b BP-HRP Bundle

    sc-549509
    200 µg Ab; 10 µg BP
    $361.00

    pan CEA (B-1) Neutralizing Peptide

    sc-398456 P
    100 µg/0.5 ml
    $69.00

    What application is the blocking peptide sc-398456 P appropriate for?

    Asked by: Randy McDonald
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Very good Western blot data of pan CEA expressionVery good Western blot data of pan CEA expression in T84 and LS1034 whole cell lysates. -SCBT QC
    Date published: 2013-03-30
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    pan CEA Antibody (B-1) is rated 5.0 out of 5 by 1.
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