palladin Antibody (E-6): sc-515799

Palladin Antibody (E-6) is a mouse monoclonal IgM antibody that detects palladin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Palladin, also known as PALLD, PNCA1, or SIH002, is a 1,383 amino acid protein that plays a crucial role in the organization of the actin cytoskeleton, which is essential for maintaining cell shape, motility, and adhesion. Anti-palladin antibody (E-6) recognizes a protein localized in both the cytoplasm and cytoskeleton featuring five immunoglobulin-like domains, contributing to structural integrity and functional versatility. Palladin is expressed in various tissues, including kidney, prostate, ovary, and colon, and exists as several alternatively spliced isoforms, which may have distinct functional roles. Palladin interacts with key proteins such as Eps8, LASP-1, and VASP, highlighting importance in cytoskeletal scaffolding and actin remodeling. Palladin undergoes post-translational modifications, including phosphorylation on specific serine residues in response to DNA damage, which can influence activity and interactions. Defects in the gene encoding palladin have been linked to increased genetic susceptibility to pancreatic cancer, underscoring potential role in tumorigenesis and making palladin a significant target for cancer research.

The preferred palladin antibody is palladin Antibody (G-2): sc-166563.