Paip2 Antibody (A-2): sc-376970
- Paip2 Antibody (A-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 13-49 near the N-terminus of Paip2 of human origin
- recommended for detection of Paip2 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Paip2 Antibody (A-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Paip2 Antibody (A-2) (see ordering information below).
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Paip2 Antibody (A-2) is a mouse monoclonal IgG1 antibody that detects Paip2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Paip2 plays a crucial role in translation regulation by interacting with polyadenylate-binding protein (PABP), which is essential for mRNA stability and translation efficiency. Specifically, Paip2 competes with Paip1 for binding to PABP, thereby repressing translation when necessary. Paip2 contains two distinct binding sites for PABP, allowing formation of a trimeric complex that can inhibit PABP binding to poly(A) RNA, which is vital for the translation process. This inhibition highlights the regulatory mechanism by which Paip2 can modulate gene expression in response to cellular conditions. The human Paip2 gene is located on chromosome 5q31 and encodes a 127 amino acid protein, underscoring its importance in post-transcriptional regulation. Anti-Paip2 antibody (A-2) serves as an invaluable tool for researchers studying translation regulation and its implications in various biological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paip2 Antibody (A-2) | sc-376970 | 200 µg/ml | $316.00 | |||
Paip2 Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-540677 | 200 µg Ab; 10 µg BP | $354.00 | |||
Paip2 Antibody (A-2): m-IgG1 BP-HRP Bundle | sc-542292 | 200 µg Ab; 20 µg BP | $354.00 | |||
Paip2 (A-2) Neutralizing Peptide | sc-376970 P | 100 µg/0.5 ml | $68.00 |