PAF acetylhydrolase 2 Antibody (B-6): sc-390508
- PAF acetylhydrolase 2 Antibody (B-6) is a mouse monoclonal IgG1 κ PAF acetylhydrolase 2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 167-201 within an internal region of PAF acetylhydrolase 2 of human origin
- PAF acetylhydrolase 2 Antibody (B-6) is recommended for detection of PAF acetylhydrolase 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PAF acetylhydrolase 2 Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PAF acetylhydrolase 2 Antibody (B-6) for WB applications. This reagent is now offered in a bundle with PAF acetylhydrolase 2 Antibody (B-6) (see ordering information below).
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PAF acetylhydrolase 2 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects PAF acetylhydrolase 2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PAF acetylhydrolase 2 antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PAF acetylhydrolase 2, also known as PAFAH2, is a 392 amino acid cytoplasmic protein that plays a crucial role in lipid metabolism by hydrolyzing platelet-activating factor (PAF), a potent phospholipid mediator involved in inflammation and thrombosis. PAF acetylhydrolase 2′s ability to regulate PAF levels is vital for maintaining homeostasis in immune responses and preventing excessive inflammatory reactions. PAFAH2 is predominantly expressed in B- and T-lymphocytes, highlighting its importance in immune function, while PAFAH2′s restricted expression in the amygdala and frontal cortex of the brain suggests a potential role in neuroinflammatory processes. The gene encoding PAF acetylhydrolase 2 is located on human chromosome 1p36.11, a region associated with various diseases, underscoring the significance of PAFAH2 in both health and disease contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PAF acetylhydrolase 2 Antibody (B-6) References:
- Gaucher disease and parkinsonism: a phenotypic and genotypic characterization. | Tayebi, N., et al. 2001. Mol Genet Metab. 73: 313-21. PMID: 11509013
- Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred. | Plasilova, M., et al. 2004. Eur J Hum Genet. 12: 365-71. PMID: 14735163
- A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease. | Unno, N., et al. 2006. J Surg Res. 134: 36-43. PMID: 16650870
- Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia. | Umemura, K., et al. 2007. Stroke. 38: 1063-8. PMID: 17272759
- Fas-associated factor 1 and Parkinson's disease. | Betarbet, R., et al. 2008. Neurobiol Dis. 31: 309-15. PMID: 18573343
- Analysis of the vitreous membrane in a case of type 1 Stickler syndrome. | Yokoi, T., et al. 2009. Graefes Arch Clin Exp Ophthalmol. 247: 715-8. PMID: 19089441
- cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. | Hattori, K., et al. 1996. J Biol Chem. 271: 33032-8. PMID: 8955149
- Platelet-activating factor acetylhydrolases. | Stafforini, DM., et al. 1997. J Biol Chem. 272: 17895-8. PMID: 9218411
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAF acetylhydrolase 2 Antibody (B-6) | sc-390508 | 200 µg/ml | $322.00 | |||
PAF acetylhydrolase 2 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-526165 | 200 µg Ab; 10 µg BP | $361.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) AC | sc-390508 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) HRP | sc-390508 HRP | 200 µg/ml | $322.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) FITC | sc-390508 FITC | 200 µg/ml | $336.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) PE | sc-390508 PE | 200 µg/ml | $349.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) Alexa Fluor® 488 | sc-390508 AF488 | 200 µg/ml | $364.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) Alexa Fluor® 546 | sc-390508 AF546 | 200 µg/ml | $364.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) Alexa Fluor® 594 | sc-390508 AF594 | 200 µg/ml | $364.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) Alexa Fluor® 647 | sc-390508 AF647 | 200 µg/ml | $364.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) Alexa Fluor® 680 | sc-390508 AF680 | 200 µg/ml | $364.00 | |||
PAF acetylhydrolase 2 Antibody (B-6) Alexa Fluor® 790 | sc-390508 AF790 | 200 µg/ml | $364.00 | |||
PAF acetylhydrolase 2 (B-6) Neutralizing Peptide | sc-390508 P | 100 µg/0.5 ml | $69.00 |