PADI4 Antibody (C-3): sc-166645
- PADI4 Antibody (C-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 239-270 within an internal region of PADI4 of human origin
- recommended for detection of PADI4 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PADI4 Antibody (C-3) for WB applications. These reagents are now offered in bundles with PADI4 Antibody (C-3) (see ordering information below).
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PADI4 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects protein arginine deiminase 4 (PADI4) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PADI4 plays a crucial role in the post-translational modification of proteins by catalyzing the conversion of arginine residues to citrulline, a process known as deimination. This modification is particularly significant in the context of autoimmune diseases, as increased citrullination of proteins has been implicated in the pathogenesis of rheumatoid arthritis. The presence of PADI4 in synovial tissues of affected individuals suggests a contribution to inflammatory processes characteristic of the disease. Additionally, anti-PADI4 antibody (C-3) detects expression primarily in the cytoplasm of eosinophils and neutrophils, highlighting PADI4′s importance in immune responses and inflammation. PADI4 monoclonal antibody (C-3) enables researchers to gain valuable insights into PADI4′s role in various biological processes and disease mechanisms, making this tool essential for studies focused on autoimmune disorders and related fields.
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PADI4 Antibody (C-3) References:
- PADI4 polymorphisms and related haplotype in rheumatoid arthritis patients. | Abd-Allah, SH., et al. 2012. Joint Bone Spine. 79: 124-8. PMID: 21981985
- Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. | Wang, Y., et al. 2021. Sci Adv. 7: PMID: 34452909
- PADI4 promotes epithelial-mesenchymal transition(EMT) in gastric cancer via the upregulation of interleukin 8. | Chang, XT., et al. 2022. BMC Gastroenterol. 22: 25. PMID: 35045833
- Biochemical and biophysical characterization of PADI4 supports its involvement in cancer. | Neira, JL., et al. 2022. Arch Biochem Biophys. 717: 109125. PMID: 35081374
- Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis. | Young, C., et al. 2022. Biol Open. 11: PMID: 35603697
- Berberine regulates PADI4-related macrophage function to prevent lung cancer. | Gu, W., et al. 2022. Int Immunopharmacol. 110: 108965. PMID: 35764017
- PADI4 and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus and juvenile idiopathic arthritis, a systematic review and meta-analysis. | Zheng, B., et al. 2023. Medicine (Baltimore). 102: e33700. PMID: 37145011
- Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells. | Singh, AK., et al. 2023. Philos Trans R Soc Lond B Biol Sci. 378: 20220236. PMID: 37778387
- hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50. | Osei-Amponsa, V., et al. 2024. Mol Cell. 84: 522-537.e8. PMID: 38151017
- Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages. | Yu, X., et al. 2024. JCI Insight. 9: PMID: 39405117
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PADI4 Antibody (C-3) | sc-166645 | 200 µg/ml | $322.00 | |||
PADI4 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-537513 | 200 µg Ab; 10 µg BP | $361.00 | |||
PADI4 Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-534800 | 200 µg Ab; 40 µg BP | $361.00 | |||
PADI4 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-545207 | 200 µg Ab; 20 µg BP | $361.00 | |||
PADI4 (C-3) Neutralizing Peptide | sc-166645 P | 100 µg/0.5 ml | $69.00 |