PACSIN2 Antibody (F-12): sc-390136

PACSIN2 Antibody (F-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects PACSIN2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PACSIN2 antibody (F-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PACSIN2, a member of the PACSIN family of cytoplasmic adapter proteins, plays a crucial role in regulating endocytotic processes, which are vital for cellular communication and nutrient uptake. PACSIN2 shows a vesicle-like distribution within cells, indicating involvement in trafficking membrane-bound vesicles. This localization suggests PACSIN2 may facilitate receptor and protein internalization, influencing various signaling pathways and maintaining cellular homeostasis. PACSIN2 interacts with several proteins, including syndapin 1, FAP52, EM13, and PSTPIP, which are implicated in cytoskeletal organization and cellular signaling. PACSIN2′s widespread expression, in contrast to PACSIN1′s restricted expression in terminally differentiated neural tissue, highlights PACSIN2′s importance in diverse biological processes across different cell types.

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PACSIN2 Antibody (F-12) References:

1. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.  |  Ritter, B., et al. 1999. FEBS Lett. 454: 356-62. PMID: 10431838
2. PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.  |  Nguyen, LP., et al. 2020. J Virol. 94: PMID: 31801866
3. A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.  |  Malinova, TS., et al. 2021. Nat Commun. 12: 2610. PMID: 33972531
4. Super-resolution analysis of PACSIN2 and EHD2 at caveolae.  |  Nishimura, T. and Suetsugu, S. 2022. PLoS One. 17: e0271003. PMID: 35834519
5. PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells.  |  Zudeh, G., et al. 2023. Life Sci Alliance. 6: PMID: 36596605
6. PACSIN2 regulates platelet integrin β1 hemostatic function.  |  Biswas, R., et al. 2023. J Thromb Haemost. 21: 3619-3632. PMID: 37678551
7. Molecular cloning of an echinococcal microtrichal antigen immunoreactive in Echinococcus multilocularis disease.  |  Frosch, PM., et al. 1993. Mol Biochem Parasitol. 58: 301-10. PMID: 8479454
8. FAP52, a novel, SH3 domain-containing focal adhesion protein.  |  Meriläinen, J., et al. 1997. J Biol Chem. 272: 23278-84. PMID: 9287337
9. Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein.  |  Wu, Y., et al. 1998. J Biol Chem. 273: 5765-70. PMID: 9488710
10. PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells.  |  Plomann, M., et al. 1998. Eur J Biochem. 256: 201-11. PMID: 9746365
11. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.  |  Qualmann, B., et al. 1999. Mol Biol Cell. 10: 501-13. PMID: 9950691

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PACSIN2 Antibody (F-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PACSIN2 Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PACSIN2 Antibody (F-12) Specifications

Alternate Product Name: PACSIN2

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 171-316

Epitope Target: PACSIN2

Epitope Species: human

Product Reactivity/Detection: PACSIN2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PACSIN2 Antibody (F-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin