PABPC1L Antibody (H-1): sc-515476

PABPC1L Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PABPC1L of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PABPC1L antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PABPC1L plays a crucial role in mRNA metabolism, particularly in regulating mRNA stability and translation, which is essential for proper gene expression and cellular function. PABPC1L is predominantly located in the cytoplasm, where PABPC1L interacts with mRNA and other RNA-binding proteins, facilitating transport and degradation of mRNA. Understanding PABPC1L dynamics and interactions is vital, as dysregulation of mRNA metabolism can lead to various diseases, including cancer and neurodegenerative disorders. Additionally, chromosome 20, where PABPC1L gene is located, harbors numerous genes expressed in the epididymis, which are thought to be important for seminal production and may serve as potential targets for male contraception. The presence of the PRNP gene, associated with prion diseases, and other genetic conditions linked to chromosome 20 further underscores the significance of studying PABPC1L in the context of both normal physiology and disease.

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PABPC1L Antibody (H-1) References:

1. Does PRNP gene control the clinical and pathological phenotype of human spongiform transmissible encephalopathies?  |  Masullo, C. and Macchi, G. 2001. Clin Neuropathol. 20: 19-25. PMID: 11220690
2. Gerstmann-Sträussler-Scheinker syndrome,fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies.  |  Collins, S., et al. 2001. J Clin Neurosci. 8: 387-97. PMID: 11535002
3. Early pattern of epilepsy in the ring chromosome 20 syndrome.  |  Ville, D., et al. 2006. Epilepsia. 47: 543-9. PMID: 16529619
4. Trisomy 20 mosaicism and nonmosaic trisomy 20: a report of 2 cases.  |  Joó, JG., et al. 2006. J Reprod Med. 51: 209-12. PMID: 16674019
5. Eppin: an epididymal protease inhibitor and a target for male contraception.  |  O'Rand, MG., et al. 2007. Soc Reprod Fertil Suppl. 63: 445-53. PMID: 17566290
6. A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis.  |  Lundwall, A. 2007. Asian J Androl. 9: 540-4. PMID: 17589793
7. Ring chromosome 20 syndrome without deletions of the subtelomeric and CHRNA4--KCNQ2 genes loci.  |  Elghezal, H., et al. 2007. Eur J Med Genet. 50: 441-5. PMID: 17851150
8. Cellular pathways leading to neuronal dysfunction and degeneration.  |  Kazantsev, AG. 2007. Drug News Perspect. 20: 501-9. PMID: 18080037
9. Bi-allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility.  |  Wang, W., et al. 2023. EMBO Mol Med. 15: e17177. PMID: 37052235
10. Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility.  |  Wang, X., et al. 2023. Clin Genet. 104: 648-658. PMID: 37723834
11. PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma.  |  Shu, G., et al. 2024. Cancer Res. 84: 1659-1679. PMID: 38382068
12. The prion diseases.  |  Prusiner, SB. 1998. Brain Pathol. 8: 499-513. PMID: 9669700

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PABPC1L Antibody (H-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PABPC1L Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PABPC1L Antibody (H-1) Specifications

Alternate Product Name: PABPC1L

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 485-529

Epitope Target: PABPC1L

Epitope Species: mouse

Product Reactivity/Detection: PABPC1L

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PABPC1L Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PABP antibody is PABP Antibody (10E10): sc-32318.