p70 S6 kinase/S6K1 Antibody (B-5): sc-393967

p70 S6 kinase α Antibody (B-5) is a mouse monoclonal IgG2a kappa light chain antibody raised against amino acids 261-430 mapping within an internal region of p70 S6 kinase α of human origin. anti-p70 S6 kinase α antibody (B-5) detects p70 S6 kinase α and p70 S6 kinase β in samples from mouse, rat, human, and additional species including equine, canine, bovine, porcine, and avian by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p70 S6 kinase α, also known as S6K1 or RPS6KB1, is a serine/threonine kinase integral to the mTOR (mechanistic Target of Rapamycin) signaling pathway, playing a crucial role in regulating cell growth, protein synthesis, and metabolism by phosphorylating the 40S ribosomal protein S6. p70 S6 kinase α is predominantly localized in the cytoplasm but translocates to the nucleus upon activation, allowing p70 S6 kinase α to phosphorylate nuclear targets involved in cell cycle progression and proliferation. This dynamic subcellular localization enables p70 S6 kinase α to modulate diverse cellular processes depending on its position within the cell, thereby influencing functions such as protein synthesis, cell growth, and metabolic regulation. Aberrations in p70 S6 kinase α activity and localization are associated with various pathological conditions including cancer, obesity, and type 2 diabetes, underscoring its significance in biomedical research. p70 S6 kinase α monoclonal antibody (B-5) is available in non-conjugated form as well as multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and a range of Alexa Fluor® conjugates, offering versatility for a wide array of experimental applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p70 S6 kinase/S6K1 Antibody (B-5) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-p70 S6 kinase/S6K1 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p70 S6 kinase/S6K1 Antibody (B-5) Specifications

Alternate Product Name: p70S6K

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 261-430

Epitope Target: p70 S6 kinase α

Epitope Species: human

Product Reactivity/Detection: p70 S6 kinase α and p70 S6 kinase β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for p70 S6 kinase/S6K1 Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p70 S6 kinase/S6K1 antibody is p70 S6 kinase/S6K1 Antibody (H-9): sc-8418.