p57 Kip2 Antibody (KP39): sc-56341
- p57 Kip2 Antibody (KP39) is a mouse monoclonal IgG2b κ p57 Kip2 antibody, cited in 22 publications, provided at 200 µg/ml
- raised against full length p57 Kip2 of human origin
- p57 Kip2 Antibody (KP39) is recommended for detection of p57 Kip2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-p57 Kip2 Antibody (KP39) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for p57 Kip2 Antibody (KP39) for WB and IHC(P) applications. These reagents are now offered in bundles with p57 Kip2 Antibody (KP39) (see ordering information below).
QUICK LINKS
SEE ALSO...
p57 Kip2 Antibody (KP39) is a mouse monoclonal IgG2b kappa light chain antibody that detects p57 Kip2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p57 Kip2 Antibody (KP39) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p57 Kip2 protein plays a crucial role in regulating cell cycle progression by acting as a potent inhibitor of cyclin-dependent kinases (Cdks), specifically targeting several G1 cyclin/Cdk complexes. This regulation is vital for maintaining proper cell division and preventing uncontrolled proliferation, which can lead to tumorigenesis. Unlike other members of the p21 Waf1/Cip1 family, p57 Kip2 functions independently of p53 in the cell cycle control mechanism. p57 Kip2′s ability to arrest cells in the G1 phase highlights its importance in cellular responses to growth signals and stress, making p57 Kip2 a significant focus for research in cancer biology and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p57 Kip2 Antibody (KP39) References:
- Transcriptional regulation of p57kip2 expression during development, differentiation and disease. | Rossi, MN., et al. 2018. Front Biosci (Landmark Ed). 23: 83-108. PMID: 28930539
- p57Kip2 imposes the reserve stem cell state of gastric chief cells. | Lee, JH., et al. 2022. Cell Stem Cell. 29: 826-839.e9. PMID: 35523142
- p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation. | Creff, J., et al. 2023. Cell Rep. 42: 112659. PMID: 37327110
- Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. | Lee, MH., et al. 1995. Genes Dev. 9: 639-49. PMID: 7729683
- p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. | Matsuoka, S., et al. 1995. Genes Dev. 9: 650-62. PMID: 7729684
- p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. | Hannon, GJ. and Beach, D. 1994. Nature. 371: 257-61. PMID: 8078588
- A cell cycle-regulated inhibitor of cyclin-dependent kinases. | Hengst, L., et al. 1994. Proc Natl Acad Sci U S A. 91: 5291-5. PMID: 8202483
- WAF1, a potential mediator of p53 tumor suppression. | el-Deiry, WS., et al. 1993. Cell. 75: 817-25. PMID: 8242752
- p21 is a universal inhibitor of cyclin kinases. | Xiong, Y., et al. 1993. Nature. 366: 701-4. PMID: 8259214
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | Serrano, M., et al. 1993. Nature. 366: 704-7. PMID: 8259215
- p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. | Polyak, K., et al. 1994. Genes Dev. 8: 9-22. PMID: 8288131
- Mammalian G1 cyclins. | Sherr, CJ. 1993. Cell. 73: 1059-65. PMID: 8513492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p57 Kip2 Antibody (KP39) | sc-56341 | 200 µg/ml | $316.00 | |||
p57 Kip2 Antibody (KP39): m-IgG Fc BP-HRP Bundle | sc-525656 | 200 µg Ab; 10 µg BP | $354.00 | |||
p57 Kip2 Antibody (KP39): m-IgG2b BP-HRP Bundle | sc-549608 | 200 µg Ab; 10 µg BP | $354.00 | |||
p57 Kip2 Antibody (KP39) AC | sc-56341 AC | 500 µg/ml, 25% agarose | $416.00 | |||
p57 Kip2 Antibody (KP39) HRP | sc-56341 HRP | 200 µg/ml | $316.00 | |||
p57 Kip2 Antibody (KP39) FITC | sc-56341 FITC | 200 µg/ml | $330.00 | |||
p57 Kip2 Antibody (KP39) PE | sc-56341 PE | 200 µg/ml | $343.00 | |||
p57 Kip2 Antibody (KP39) Alexa Fluor® 488 | sc-56341 AF488 | 200 µg/ml | $357.00 | |||
p57 Kip2 Antibody (KP39) Alexa Fluor® 546 | sc-56341 AF546 | 200 µg/ml | $357.00 | |||
p57 Kip2 Antibody (KP39) Alexa Fluor® 594 | sc-56341 AF594 | 200 µg/ml | $357.00 | |||
p57 Kip2 Antibody (KP39) Alexa Fluor® 647 | sc-56341 AF647 | 200 µg/ml | $357.00 | |||
p57 Kip2 Antibody (KP39) Alexa Fluor® 680 | sc-56341 AF680 | 200 µg/ml | $357.00 | |||
p57 Kip2 Antibody (KP39) Alexa Fluor® 790 | sc-56341 AF790 | 200 µg/ml | $357.00 |