p57 Kip2 Antibody (3F244): sc-71824

p57 Kip2 Antibody (3F244) is a mouse monoclonal IgG2b antibody that detects p57 Kip2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p57 Kip2, also known as Kip2, is a crucial member of the p21 Waf1/Cip1/p27 family of cyclin-dependent kinase inhibitors, playing a significant role in regulating cell cycle progression by inhibiting several G1 cyclin/Cdk complexes. This inhibition is vital for maintaining proper cell cycle control, particularly in response to cellular stress or DNA damage, as p57 Kip2 prevents premature progression into the S phase, thereby allowing time for DNA repair mechanisms to function effectively. Notably, p57 Kip2 is not regulated by p53, which distinguishes p57 Kip2 from other family members like p21 Waf1/Cip1, and p57 Kip2 overexpression can lead to a robust G1 arrest, highlighting p57 Kip2′s potential as a therapeutic target in cancer where cell cycle dysregulation is prevalent. Anti-p57 Kip2 antibody (3F244) is an essential tool for researchers investigating the intricate mechanisms of cell cycle regulation and the implications of mitotic inhibitors in various biological contexts.

The preferred p57 Kip2 antibody is p57 Kip2 Antibody (KP39): sc-56341.