p39 Antibody (F-4): sc-365781

p39 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects p39 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-p39 antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p39 protein plays a crucial role in regulating cyclin-dependent kinase 5 (Cdk5), which is essential for proper neuronal development and function in the mammalian central nervous system. p39 (F-4) monoclonal antibody recognizes p39 protein, which interacts with Cdk5 and modulates actin cytoskeletal dynamics by localizing to lamellipodial and filopodial structures in cells, as well as growth cones of neurons. This localization suggests p39 may influence neuronal morphology and synaptic plasticity, vital for learning and memory processes. Human p39 gene is located on chromosome 2q35 and encodes a 367-amino acid protein that shares limited similarity with cyclins, indicating p39 and p35 may represent a distinct family of cyclin-dependent kinase activating proteins. During embryonic brain development in rats, p39 expression shows an inverse relationship with Cdk5 and p35, suggesting region-specific and developmental stage-specific roles in the brain. p39 temporal and spatial expression at synaptic junctions further underscores potential involvement in synaptic signaling and plasticity, making p39 a valuable target for neurobiology research.

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p39 Antibody (F-4) References:

1. Immunohistochemical localization of CDK5 activator p39 in the rat brain.  |  Honjyo, Y., et al. 1999. Neuroreport. 10: 3375-9. PMID: 10599848
2. Synaptic localization of p39, a neuronal activator of cdk5.  |  Humbert, S., et al. 2000. Neuroreport. 11: 2213-6. PMID: 10923673
3. The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains.  |  Wu, DC., et al. 2000. Neurochem Res. 25: 923-9. PMID: 10959488
4. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.  |  Ko, J., et al. 2001. J Neurosci. 21: 6758-71. PMID: 11517264
5. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.  |  Tang, D., et al. 1995. J Biol Chem. 270: 26897-903. PMID: 7592934
6. Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development.  |  Cai, XH., et al. 1997. Neurosci Res. 28: 355-60. PMID: 9274831

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p39 Antibody (F-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p39 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p39 Antibody (F-4) Specifications

Alternate Product Name: p39

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 6-75

Epitope Target: p39

Epitope Species: human

Product Reactivity/Detection: p39

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p39 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin