p38 beta MAPK11 Antibody (BB10): sc-33689

p38 beta MAPK11 Antibody (BB10) is a mouse monoclonal IgG1 antibody that detects p38 beta MAPK11 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p38 beta MAPK11, a member of the mitogen-activated protein kinase (MAPK) family, plays a crucial role in various cellular processes, including stress responses, inflammation, and cell differentiation. p38 beta MAPK11 is primarily located in the cytoplasm and can translocate to the nucleus in response to specific stimuli, which is vital for regulating gene expression and cellular responses to environmental changes. The ability of p38 beta MAPK11 to shuttle between cellular compartments underscores its importance in mediating signaling pathways that influence cell fate decisions. p38 beta MAPK11 interacts with several key proteins, including MKK3 and MKK6, which are upstream activators that phosphorylate p38 MAPK, thereby enhancing activity and facilitating downstream signaling events. Phosphorylation of p38 beta MAPK11 on specific threonine and tyrosine residues is essential for activation, allowing participation in critical processes such as cytokine production and apoptosis. With a significant role in cellular signaling and response mechanisms, p38 beta MAPK11 is a valuable target for research in various fields, including cancer biology and immunology.

The preferred p38 alpha/beta MAPK antibody is p38 alpha/beta MAPK Antibody (A-12): sc-7972.