P2Y2 Antibody (H-5): sc-518121
- P2Y2 Antibody (H-5) is a mouse monoclonal IgG3 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 352-379 at the C-terminus of P2Y2 of human origin
- recommended for detection of P2Y2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-P2Y2 Antibody (H-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for P2Y2 Antibody (H-5) for WB applications. This reagent is now offered in a bundle with P2Y2 Antibody (H-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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P2Y2 Antibody (H-5) is a mouse monoclonal IgG3 kappa light chain antibody that detects P2Y2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-P2Y2 antibody (H-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. P2Y2 (H-5) antibody targets a G protein-coupled receptor that mediates extracellular nucleotide effects, primarily through phospholipase C activation, which is vital for cellular processes such as proliferation, differentiation, and cytokine release. P2Y2 plays a key role in inflammation and vascular damage, showing differential expression in heart, lung, and brain tissues, while maintaining universal presence in leukocytes. P2Y2 (H-5) monoclonal antibody enables research into nucleotide signaling pathways, particularly through P2Y2′s ability to activate potassium channels and inhibit adenylate cyclase and N-type calcium channels, making this antibody valuable for studies focused on immune responses and cardiovascular functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
P2Y2 Antibody (H-5) References:
- Molecular determinants of P2Y2 nucleotide receptor function: implications for proliferative and inflammatory pathways in astrocytes. | Weisman, GA., et al. 2005. Mol Neurobiol. 31: 169-83. PMID: 15953819
- P2Y2 nucleotide receptor-mediated responses in brain cells. | Peterson, TS., et al. 2010. Mol Neurobiol. 41: 356-66. PMID: 20387013
- Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. | Vallon, V. and Rieg, T. 2011. Am J Physiol Renal Physiol. 301: F463-75. PMID: 21715471
- P2Y2 receptor agonists for the treatment of dry eye disease: a review. | Lau, OC., et al. 2014. Clin Ophthalmol. 8: 327-34. PMID: 24511227
- P2Y2 R activation by nucleotides promotes skin wound-healing process. | Jin, H., et al. 2014. Exp Dermatol. 23: 480-5. PMID: 24816122
- The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. | Xing, Y., et al. 2014. PLoS One. 9: e108417. PMID: 25268784
- Upregulation of P2Y2 nucleotide receptor in human hepatocellular carcinoma cells. | Tak, E., et al. 2016. J Int Med Res. 44: 1234-1247. PMID: 27807254
- Excessive Extracellular ATP Desensitizes P2Y2 and P2X4 ATP Receptors Provoking Surfactant Impairment Ending in Ventilation-Induced Lung Injury. | Hasan, D., et al. 2018. Int J Mol Sci. 19: PMID: 29652806
- Cell-type-specific role of P2Y2 receptor in HDM-driven model of allergic airway inflammation. | Schneble, D., et al. 2023. Front Immunol. 14: 1209097. PMID: 37790940
- G protein coupled P2Y2 receptor as a regulatory molecule in cancer progression. | Zhang, WJ., et al. 2024. Arch Biochem Biophys. 762: 110194. PMID: 39486566
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P2Y2 Antibody (H-5) | sc-518121 | 200 µg/ml | $316.00 | |||
P2Y2 Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-525386 | 200 µg Ab, 40 µg BP | $354.00 | |||
P2Y2 Antibody (H-5) AC | sc-518121 AC | 500 µg/ml, 25% agarose | $416.00 | |||
P2Y2 Antibody (H-5) HRP | sc-518121 HRP | 200 µg/ml | $316.00 | |||
P2Y2 Antibody (H-5) FITC | sc-518121 FITC | 200 µg/ml | $330.00 | |||
P2Y2 Antibody (H-5) PE | sc-518121 PE | 200 µg/ml | $343.00 | |||
P2Y2 Antibody (H-5) Alexa Fluor® 488 | sc-518121 AF488 | 200 µg/ml | $357.00 | |||
P2Y2 Antibody (H-5) Alexa Fluor® 546 | sc-518121 AF546 | 200 µg/ml | $357.00 | |||
P2Y2 Antibody (H-5) Alexa Fluor® 594 | sc-518121 AF594 | 200 µg/ml | $357.00 | |||
P2Y2 Antibody (H-5) Alexa Fluor® 647 | sc-518121 AF647 | 200 µg/ml | $357.00 | |||
P2Y2 Antibody (H-5) Alexa Fluor® 680 | sc-518121 AF680 | 200 µg/ml | $357.00 | |||
P2Y2 Antibody (H-5) Alexa Fluor® 790 | sc-518121 AF790 | 200 µg/ml | $357.00 |