P2X7 Antibody (Hano43): sc-134224
- P2X7 Antibody (Hano43) is a rat monoclonal IgG2b, cited in 5 publications, provided at 200 µg/ml
- genetically immunized with cDNA encoding P2X7 of mouse origin
- recommended for detection of P2X7 of mouse and rat origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for P2X7 Antibody (Hano43). This work is in progress.
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P2X7 Antibody (Hano43) is a rat monoclonal IgG2b antibody that detects P2X7 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). P2X7 is a member of the P2X receptor family, which consists of ligand-gated ion channels that facilitate the influx of calcium ions into cells in response to extracellular ATP. P2X7 is predominantly located in the plasma membrane of various cell types, including immune cells, neurons, and epithelial cells, playing a crucial role in mediating inflammatory responses and cell signaling. P2X7 is unique in its ability to form large pores in the membrane upon prolonged activation, which can lead to the release of pro-inflammatory cytokines and contribute to processes such as necrosis and apoptosis. Understanding the function and location of P2X7 is vital, as P2X7 is implicated in various pathological conditions, including chronic inflammation, neurodegenerative diseases, and cancer. Anti-P2X7 antibody (Hano43) is an essential tool for researchers investigating the role of this receptor in health and disease, providing insights into its mechanisms and potential therapeutic targets.
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P2X7 Antibody (Hano43) References:
- The P2X7 Receptor-Interleukin-1 Liaison. | Giuliani, AL., et al. 2017. Front Pharmacol. 8: 123. PMID: 28360855
- The P2X7 Receptor in Infection and Inflammation. | Di Virgilio, F., et al. 2017. Immunity. 47: 15-31. PMID: 28723547
- P2X7 as a scavenger receptor for innate phagocytosis in the brain. | Gu, BJ. and Wiley, JS. 2018. Br J Pharmacol. 175: 4195-4208. PMID: 30098011
- P2X7 Receptor-Mediated Inflammation in Cardiovascular Disease. | Zhou, J., et al. 2021. Front Pharmacol. 12: 654425. PMID: 33995071
- P2X7-dependent immune pathways in retinal diseases. | Déchelle-Marquet, PA., et al. 2023. Neuropharmacology. 223: 109332. PMID: 36372269
- P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission. | Vitureira, N., et al. 2024. Purinergic Signal. 20: 223-236. PMID: 37713157
- Involvement of microglial P2X7 receptor in pain modulation. | Zhang, J., et al. 2024. CNS Neurosci Ther. 30: e14496. PMID: 37950524
- Tumour immune escape via P2X7 receptor signalling. | Sainz, RM., et al. 2023. Front Immunol. 14: 1287310. PMID: 38022596
- Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases. | Zheng, H., et al. 2024. Front Immunol. 15: 1345625. PMID: 38370420
- Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells. | Maldifassi, MC., et al. 2024. Br J Pharmacol. 181: 2905-2922. PMID: 38679932
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P2X7 Antibody (Hano43) | sc-134224 | 200 µg/ml | $322.00 | |||
P2X7 Antibody (Hano43) FITC | sc-134224 FITC | 200 µg/ml | $336.00 | |||
P2X7 Antibody (Hano43) PE | sc-134224 PE | 200 µg/ml | $349.00 |