P2X7 Antibody (Hano43): sc-134224

P2X7 Antibody (Hano43) is a rat monoclonal IgG2b antibody that detects P2X7 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). P2X7 is a member of the P2X receptor family, which consists of ligand-gated ion channels that facilitate the influx of calcium ions into cells in response to extracellular ATP. P2X7 is predominantly located in the plasma membrane of various cell types, including immune cells, neurons, and epithelial cells, playing a crucial role in mediating inflammatory responses and cell signaling. P2X7 is unique in its ability to form large pores in the membrane upon prolonged activation, which can lead to the release of pro-inflammatory cytokines and contribute to processes such as necrosis and apoptosis. Understanding the function and location of P2X7 is vital, as P2X7 is implicated in various pathological conditions, including chronic inflammation, neurodegenerative diseases, and cancer. Anti-P2X7 antibody (Hano43) is an essential tool for researchers investigating the role of this receptor in health and disease, providing insights into its mechanisms and potential therapeutic targets.

The preferred P2X7 antibody is P2X7 Antibody (D-1): sc-514962.