P2X6 Antibody (D-1): sc-166013

P2X6 Antibody (D-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects P2X6 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-P2X6 antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. P2X6 is a member of the P2X receptor family, which consists of ligand-gated ion channels that facilitate calcium ion influx into cells in response to extracellular ATP. These receptors play a crucial role in mediating synaptic transmission between neurons and other tissues, acting as a key component in neurotransmission. P2X6 is primarily located in the central nervous system and is involved in various physiological processes, including pain perception and neuroinflammation. P2X6 interaction with other proteins, such as P2X4 and P2X7, can modulate activity and influence cellular responses to ATP, highlighting importance in both normal and pathological conditions. Understanding P2X6 function and interactions is essential for elucidating role in neurobiology and potential therapeutic targets for neurological disorders.

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P2X6 Antibody (D-1) References:

1. Cytolytic P2X purinoceptors.  |  Di Virgilio, F., et al. 1998. Cell Death Differ. 5: 191-9. PMID: 10200464
2. Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.  |  Alexander, K., et al. 1999. J Pharmacol Exp Ther. 291: 1135-42. PMID: 10565834
3. Inactivation of P2X2 purinoceptors by divalent cations.  |  Ding, S. and Sachs, F. 2000. J Physiol. 522 Pt 2: 199-214. PMID: 10639098
4. Evidence for P2X(3), P2X(4), P2X(5) but not for P2X(7) containing purinergic receptors in Müller cells of the rat retina.  |  Jabs, R., et al. 2000. Brain Res Mol Brain Res. 76: 205-10. PMID: 10762695
5. A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.  |  Oury, C., et al. 2000. J Biol Chem. 275: 22611-4. PMID: 10816552
6. P2X receptors in sensory neurones.  |  Burnstock, G. 2000. Br J Anaesth. 84: 476-88. PMID: 10823099
7. Pharmacology of cloned P2X receptors.  |  North, RA. and Surprenant, A. 2000. Annu Rev Pharmacol Toxicol. 40: 563-80. PMID: 10836147
8. The human P2x1 receptor: molecular cloning, tissue distribution, and localization to chromosome 17.  |  Longhurst, PA., et al. 1996. Biochim Biophys Acta. 1308: 185-8. PMID: 8809107

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-P2X6 Antibody (D-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-P2X6 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

P2X6 Antibody (D-1) Specifications

Alternate Product Name: P2X6

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 351-431

Epitope Target: P2X6

Epitope Species: human

Product Reactivity/Detection: P2X6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for P2X6 Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin